食源性DPP-IV抑制肽降血糖作用机制研究进展  

Research Progress on the Mechanism of Food-derived DPP-IV Inhibitory Peptides for Hypoglycemic Effect

作　　者：赵嘉妮 陈宏 翁凌 刘光明 林家仕[1] 曹敏杰 ZHAO Jiani;CHEN Hong;WENG Ling;LIU Guangming;LIN Jiashi;CAO Minjie(College of Physical Education,Jimei University,Xiamen 361021,China;College of Food and Biological Engineering,Jimei University,Xiamen 361021,China)

机构地区：[1]集美大学体育学院,福建厦门361021 [2]集美大学食品与生物工程学院,福建厦门361021

出　　处：《食品工业科技》2021年第23期447-454,共8页Science and Technology of Food Industry

基　　金：“蓝色粮仓”国家重点研发计划项目(2018YFD0901004)。

摘　　要：随着全球糖尿病患者人数的逐年增加,传统的药物治疗方法面临严峻挑战。研究发现,饮食干预是辅助治疗糖尿病的一种有效手段。食物中的蛋白质经酶解后可产生多种生物活性肽。其中,与糖尿病防治密切相关的二肽基肽酶-IV(Dipeptidyl peptidase-IV, DPP-IV)抑制肽已从鱼类等多种食物的酶解液中被发现。海洋生物种类丰富,是制备功能性食品的重要原料来源。本文综述了食源性DPP-IV抑制肽降糖的作用机制,特别是海洋生物来源的DPP-IV抑制肽的研究进展,旨在为开发基于DPP-IV抑制肽的功能性食品提供参考。With the annual increase of diabetes patients all around the world, traditional treatment methods are encountering challenges. Research has found that dietary intervention is an effective way of adjuvant treatment of diabetes. Proteins in food can produce various bioactive peptides after enzymatic hydrolysis. Among them, dipeptidyl peptidase-IV(DPP-IV)inhibitory peptides, which are closely related to the hypoglycemic effect have been identified in enzymatic hydrolysis of fish and other foods. Marine organism is rich in species and they are important resources for preparation of functional foods. In this manuscript, the hypoglycemic mechanism of food-derived DPP-IV inhibitory peptides and the research progress of DPP-IV inhibitory peptides derived from marine organism were reviewed, with a purpose to provide a reference for the development of functional foods based on DPP-IV inhibitory peptides.

关 键 词：DPP-IV 抑制剂 II-型糖尿病 水产动物 功能性食品 

分 类 号：TS201.2[轻工技术与工程—食品科学]