Orexins:A promising target to digestive cancers,inflammation,obesity and metabolism dysfunctions  

作　　者：Alain Couvineau Thierry Voisin Pascal Nicole Valerie Gratio Anne Blais 

机构地区：[1]INSERM UMR1149/Inflammation Research Center,Team“From inflammation to cancer in digestive diseases”labeled by“la Ligue Nationale contre le Cancer”,University of Paris,DHU UNITY,Paris 75018,France [2]UMR PNCA,AgroParisTech,INRA,UniversitéParis-Saclay,Paris 75005,France

出　　处：《World Journal of Gastroenterology》2021年第44期7582-7596,共15页世界胃肠病学杂志（英文版）

基　　金：INSERM U1149/The Inflammation Research Center,Inserm Transfert,The Institut National du Cancer,No.2013-213;Ligue Nationale Contre le Cancer,No.R16020HH,GB/MA/CD/EP-12062;and AgroParisTech(INRAE and UniversitéParis-Saclay).

摘　　要：Hypothalamic neuropeptides named hypocretin/orexins which were identified in 1998 regulate critical functions such as wakefulness in the central nervous system.These past 20 years had revealed that orexins/receptors system was also present in the peripheral nervous system where they participated to the regulation of multiple functions including blood pressure regulation,intestinal motility,hormone secretion,lipolyze and reproduction functions.Associated to these peripheral functions,it was found that orexins and their receptors were involved in various diseases such as acute/chronic inflammation,metabolic syndrome and cancers.The present review suggests that orexins or the orexin neural circuitry represent potential therapeutic targets for the treatment of multiple pathologies related to inflammation including intestinal bowel disease,multiple sclerosis and septic shock,obesity and digestive cancers.

关 键 词：OREXIN NEUROPEPTIDE G-protein coupled receptor superfamily INFLAMMATION Metabolic syndrome Cancer 

分 类 号：R363[医药卫生—病理学]