多糖降血糖活性构效关系及作用机制研究进展  

Progress in Understanding the Structure-Activity Relationship and Hypoglycemic Mechanism of Polysaccharides

作　　者：杨玉洁 刘静宜 谭艳 王淑惠 陈汉民 周爱梅[1,2] YANG Yujie;LIU Jingyi;TAN Yan;WANG Shuhui;CHEN Hanmin;ZHOU Aimei(Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods,College of Food Science,South China Agricultural University,Guangzhou 510642,China;Guangdong Zhancui Food Co.,Ltd.,Chaozhou 515634,China)

机构地区：[1]华南农业大学食品学院,广东省功能食品活性物重点实验室,广东广州510642 [2]广东展翠食品股份有限公司,广东潮州515634

出　　处：《食品科学》2021年第23期355-363,共9页Food Science

基　　金：广东省“扬帆计划”引进创新创业团队项目(2016YT03S056)。

摘　　要：糖尿病是以高血糖为特征的代谢疾病,发病率逐年攀升,而以西药为主的治疗方式存在一定的副作用,这促使人们将目光转向天然的活性物质。多糖作为一种安全、低毒的天然物质,具有多种生物活性。降血糖活性是多糖的重要活性之一,极具开发潜力。本文从分子质量、单糖组成、糖苷键、高级结构和基团等方面综述了多糖降血糖活性与其结构的关系,并总结了多糖降血糖的作用机制,分析目前研究存在的问题,同时对未来研究的方向进行了总结和展望。Diabetes is a metabolic disease characterized by hyperglycemia.The incidence of diabetes has been increasing year by year.Diabetes treatments mainly with Western medicines can cause side effects,which will stimulate people to turn their attention to natural bioactive substances.As a group of safe,low-toxic natural substances,polysaccharides have many biological activities such as hypoglycemic activity and thus have great development potential.In this paper,the relationship between the hypoglycemic activity and structure of polysaccharides is reviewed with respect to molecular mass,monosaccharide composition,glycosidic bonds,advanced structures and groups,and the mechanism of the hypoglycemic action of polysaccharides is summarized.Furthermore,problems existing in this field of research and future research directions are discussed.

关 键 词：多糖 降血糖作用 构效关系 降血糖机制 

分 类 号：TS201.4[轻工技术与工程—食品科学]