Basophils as a potential therapeutic target in cancer  

作　　者：Jicheng ZHANG Hanlin YIN Qiangda CHEN Guochao ZHAO Wenhui LOU Wenchuan WU Ning PU 

机构地区：[1]Department of General Surgery,Zhongshan Hospital,Fudan University,Shanghai 200032,China [2]Cancer Center,Zhongshan Hospital,Fudan University,Shanghai 200032,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2021年第12期971-984,共14页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：supported by the Shanghai Sailing Program(No.21YF1407100);the China Postdoctoral Science Foundation(No.2021M690037);the National Natural Science Foundation of China(Nos.82103409 and 81773068);the National Key R&D Program of China(No.2019YFC1315902)。

摘　　要：Basophils,which are considered as redundant relatives of mast cells and the rarest granulocytes in peripheral circulation,have been neglected by researchers in the past decades.Previous studies have revealed their vital roles in allergic diseases and parasitic infections.Intriguingly,recent studies even reported that basophils might be associated with cancer development,as activated basophils synthesize and release a variety of cytokines and chemokines in response to cancers.However,it is still subject to debate whether basophils function as tumor-protecting or tumor-promoting components;the answer may depend on the tumor biology and the microenvironment.Herein,we reviewed the role of basophils in cancers,and highlighted some potential and promising therapeutic strategies.

关 键 词：BASOPHIL CANCER CYTOKINE CHEMOKINE Tumor microenvironment 

分 类 号：R730.5[医药卫生—肿瘤]