The role of caveolae in endothelial dysfunction  

作　　者：Jinlong He Zhen Cui Yi Zhu 

机构地区：[1]Tianjin Key Laboratory of Metabolic Diseases,The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics and Department of Physiology and Pathophysiology,Tianjin Medical University,Tianjin 300070,China [2]Department of Physiology and Pathophysiology,Tianjin Medical University,22 Qixiangtai Rd,Tianjin 300070,China

出　　处：《Medical Review》2021年第1期78-91,共14页医学评论（英文）

基　　金：supported by National Key Research and Development Program of China Grant(2019YFA0802003);National Natural Science Foundation of China Grants(81730014,81790621,82070451,and 81870313);Young Elite Scientists Sponsorship Program by CAST(2019QNRC001);Tianjin Municipal Science and Technology Project(18JCZDJC44900 and 17JCJQJC45700)。

摘　　要：Caveolae,the specialized cell-surface plasma membrane invaginations which are abundant in endothelial cells,play critical roles in regulating various cellular processes,including cholesterol homeostasis,nitric oxide production,and signal transduction.Endothelial caveolae serve as a membrane platform for compartmentalization,modulation,and integration of signal events associated with endothelial nitric oxide synthase,ATP synthaseβ,and integrins,which are involved in the regulation of endothelial dysfunction and related cardiovascular diseases,such as atherosclerosis and hypertension.Furthermore,these dynamic microdomains on cell membrane are modulated by various extracellular stimuli,including cholesterol and flow shear stress.In this brief review,we summarize the critical roles of caveolae in the orchestration of endothelial function based on recent findings as well as our work over the past two decades.

关 键 词：ATHEROSCLEROSIS CAVEOLAE CAVEOLIN-1 endothelial cell INTEGRIN shear stress. 

分 类 号：R36[医药卫生—病理学]