Role of platelet-derived extracellular vesicles in traumatic brain injury-induced coagulopathy and inflammation  

作　　者：Liang Liu Quan-Jun Deng 

机构地区：[1]Department of Neurosurgery,Tianjin Institute of Neurology,Tianjin Medical University General Hospital,Tianjin,China

出　　处：《Neural Regeneration Research》2022年第10期2102-2107,共6页中国神经再生研究（英文版）

基　　金：supported by Scientific Research Program of Tianjin Education Commission(Natural Science)of China,No.2019ZD034(to QJD).

摘　　要：Extracellular vesicles are composed of fragments of exfoliated plasma membrane,organelles or nuclei and are released after cell activation,apoptosis or destruction.Platelet-derived extracellular vesicles are the most abundant type of extracellular vesicle in the blood of patients with traumatic brain injury.Accumulated laboratory and clinical evidence shows that platelet-derived extracellular vesicles play an important role in coagulopathy and inflammation after traumatic brain injury.This review discusses the recent progress of research on platelet-derived extracellular vesicles in coagulopathy and inflammation and the potential of platelet-derived extracellular vesicles as therapeutic targets for traumatic brain injury.

关 键 词：ANGIOGENESIS clotting factors COAGULOPATHY delivery INFLAMMATION platelet-derived extracellular vesicles review TARGET traumatic brain injury 

分 类 号：R651.15[医药卫生—外科学]