Exploring the role of interleukin-27 as a regulator of neuronal survival in central nervous system diseases  

作　　者：Andrea N.Nortey Kimberly N.Garces Abigail S.Hackam 

机构地区：[1]Bascom Palmer Eye Institute,University of Miami Miller School of Medicine,Miami,FL,USA

出　　处：《Neural Regeneration Research》2022年第10期2149-2152,共4页中国神经再生研究（英文版）

基　　金：support for this work for ASH was from National Eye Institute R01 EY026546;an NEI Center Core Grant EY014801.

摘　　要：Interleukin-27 is a pleiotropic cytokine that is involved in tissue responses to infection,cell stress,neuronal disease,and tumors.Recent studies in various tissues indicate that interleukin-27 has complex activating and inhibitory properties in innate and acquired immunity.The availability of recombinant interleukin-27 protein and mice with genetic deletions of interleukin-27,its receptors and signaling mediators have helped define the role of interleukin-27 in neurodegenerative diseases.Interleukin-27 has been well-characterized as an important regulator of T cell activation and differentiation that enhances or suppresses T cell responses in autoimmune conditions in the central nervous system.Evidence is also accumulating that interleukin-27 has neuroprotective activities in the retina and brain.Interleukin-27 is secreted from and binds to infiltrating microglia,macrophage,astrocytes,and even neurons and it promotes neuronal survival by regulating pro-and anti-inflammatory cytokines,neuroinflammatory pathways,oxidative stress,apoptosis,autophagy,and epigenetic modifications.However,interleukin-27 can have the opposite effect and induce inflammation and cell death in certain situations.In this review,we describe the current understanding of regulatory activities of interleukin-27 on cell survival and inflammation and discuss its mechanisms of action in the brain,spinal cord,and retina.We also review evidence for and against the therapeutic potential of interleukin-27 for dampening harmful neuroinflammatory responses in central nervous system diseases.

关 键 词：central nervous system CYTOKINE inflammatory INTERLEUKIN-27 NEUROPROTECTION RETINA 

分 类 号：R741[医药卫生—神经病学与精神病学]