木薯淀粉介导肠道菌群加剧小鼠肥胖症的机制  

Mechanism of Cassava Starch Mediating Gut Microbiota Exacerbating Obesity in Mice

作　　者：汪媛媛 常海波 张增 张家超[1] Wang Yuanyuan;Chang Haibo;Zhang Zeng;Zhang Jiachao(College of Food Science and Engineering,Hainan University,Haikou 570228)

机构地区：[1]海南大学食品科学与工程学院,海口570228

出　　处：《中国食品学报》2022年第2期160-168,共9页Journal of Chinese Institute Of Food Science and Technology

基　　金：国家自然科学基金项目(31701577)。

摘　　要：肥胖症是体内脂肪过度积累而导致超重的一种慢性代谢疾病。木薯淀粉属于可消化淀粉,目前对其研究多集中于对结构的解析和体外功能评价方面。本研究基于小鼠肥胖模型,采用高通量测序技术研究造模肥胖小鼠摄入木薯淀粉后血液中总胆固醇(TC)、甘油三酯(TG),免疫指标免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)水平以及对小鼠肠道菌群结构的影响。结果表明:与对照组相比,TG、IgA、IgG和IgM水平均显著升高,摄入木薯淀粉促进了能高效分解代谢碳水化合物的菌属,如双歧杆菌属和多尔氏菌属相对丰度的增加,同时也促进了致病菌的增殖,如梭状芽孢杆菌属。摄入木薯淀粉促使小鼠肠道微生物组成发生改变,同时丰富的碳水化合物也给机体提供了足够的能量来源,从而增加了能量的储存,导致小鼠更容易产生肥胖症状。Obesity is a chronic metabolic disease in which excessive accumulation of body fat leads to overweight.Cassava starch is a digestible starch,and the current research on it mostly focused on structural analysis and in vitro function evaluation.This study was based on a mouse obesity model,using high-throughput sequencing technology to study the total cholesterol(TC),triglycerides(TG)and immune index immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM)in the blood of modeled obese mice after ingesting cassava starch.Studies have shown that compared with the control group,the levels of TG,IgA,IgG,and IgM were significantly higher than those in the control group.Cassava starch intake it promoted the increase of the relative abundance of bacteria that could efficiently catabolize carbohydrates such as Bifdobacterium and Dorea,but also promotes the proliferation of pathogenic bacteria such as Clostridium.Ingestion of cassava starch promoted changes in the microbial composition of the gut tract of mice.At the same time,abundant carbohydrates also provided sufficient energy sources for the body,thereby increasing energy storage and making mice more prone to obesity.

关 键 词：木薯淀粉 肥胖症 肠道微生物 16S rRNA 

分 类 号：TS201.4[轻工技术与工程—食品科学]