益生菌产生的细菌素及其功能机制  

Functions and mechanisms of bacteriocins produced by probiotics

作　　者：滕坤玲[1] 钟瑾[1,2] TENG Kunling;ZHONG Jin(State Key Laboratory of Microbial Resources,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院微生物研究所,微生物资源前期开发国家重点实验室,北京100101 [2]中国科学院大学,北京100049

出　　处：《微生物学报》2022年第3期858-868,共11页Acta Microbiologica Sinica

基　　金：国家自然科学基金(31972049,U20A2066)。

摘　　要：细菌素是细菌核糖体合成的具有抑菌活性的小肽。细菌素的产生是益生菌重要的益生特性,它们天然无毒,不仅对食品腐败菌和人体致病菌有很好的抑菌活性,还具有有助益生菌定殖和调节肠道菌群等益生特性。本文综述了益生菌产生的细菌素的种类、条件性合成、益生功能及其作用机理等,以期为深入认识益生菌的益生功能及其作用方式,研究开发对人体有益的细菌素及益生菌产品提供理论基础。Bacteriocins are ribosomally synthesized antimicrobial peptides produced by bacteria.Bacteriocin production has been considered an important trait in the selection of probiotic strains.Verified safe, they inhibit many food spoilage bacteria and pathogens. Besides, they facilitate the colonization of probiotics and regulate gut microbiota. In this article, we described the types of bacteriocins produced by probiotics, and the synthesis under specific conditions, functions, and mechanisms of them, hoping to enhance the understanding of functions and mechanisms of probiotics and lay a theoretical basis for the development of beneficial bacteriocins and probiotic products.

关 键 词：益生菌 细菌素 抑菌 定殖 肠道菌群 

分 类 号：TS201.3[轻工技术与工程—食品科学]