Emerging role of neuregulin-1beta1 in pathogenesis and progression of multiple sclerosis  

作　　者：Seyyed Mohyeddin Ziaee Soheila Karimi-Abdolrezaee 

机构地区：[1]Department of Physiology and Pathophysiology,Spinal Cord Research Center,Rady Faculty of Health Sciences,University of Manitoba,Children Hospital Research Institute of Manitoba,Winnipeg,MB,Canada

出　　处：《Neural Regeneration Research》2023年第1期133-134,共2页中国神经再生研究（英文版）

基　　金：supported by a University of Manitoba Graduate Fellowship;Graduate Enhancement of Tricouncil Supplement (GETS);Hillary Kaufman Lerner Memorial Funds;supported by the grants from Multiple Sclerosis Society of Canada (EGDI-2936, EGDI-3742);the Canadian Institute of Health Research (133721 and 156218)

摘　　要：Multiple sclerosis(MS)is a chronic immune-mediated disorder of the central nervous system(CNS)that causes focal demyelinating lesions,followed by axonal and neuronal degeneration.Several genetic and environmental factors are found to be associated with MS incidence.While MS etiology seems to be multifactorial and needs further elucidation,it is understood that the response of an immune system to specific myelin antigens triggers the onset of MS(Dendrou et al.,2015).However,how the autoimmune response initiates against myelin,and the cellular and molecular mechanisms underpinning the development and progression of MS are not fully understood.Thus,deconstructing MS pathogenesis is of paramount importance for identifying novel diagnostic and therapeutic targets for this complex disease.

关 键 词：PATHOGENESIS SCLEROSIS DEGENERATION 

分 类 号：R744.51[医药卫生—神经病学与精神病学]