绵柔型白酒对小鼠酒精性肝损伤的影响作用研究  

Effect of Mianrou-flavor Baijiu on alcoholic liver damage in mice

作　　者：戴源[1] 陈杉彬 姜欣 李红娇 姚逸萍 张晓蒙 宋涛 李一澍 赵文梅 王妍凌 王德良 DAI Yuan;CHEN Shanbin;JIANG Xin;LI Hongjiao;YAO Yiping;ZHANG Xiaomeng;SONG Tao;LI Yishu;ZHAO Wenmei;WANG Yanling;WANG Deliang(Jiangsu Yanghe Brewery Joint-Stock Co.,Ltd.,Suqian 223800,China;China National Research Institute of Food and Fermentation Industries,Beijing 100015,China;International Joint Research Center of Quality and Safety of Alcoholic Beverages,Beijing 100015,China)

机构地区：[1]江苏洋河酒厂股份有限公司,江苏宿迁223800 [2]中国食品发酵工业研究院有限公司,北京100015 [3]酒类品质与安全国际联合研究中心,北京100015

出　　处：《中国酿造》2022年第6期141-147,共7页China Brewing

摘　　要：将30只C57BL/6J小鼠随机均分为食用酒精组、绵柔型酒样1#处理组、绵柔型酒样2#处理组,分别灌胃相同剂量的52%vol食用酒精、52%vol绵柔型酒样1#、52%vol绵柔型酒样2#。与食用酒精组相比,绵柔型酒样组小鼠谷丙转氨酶(ALT)和谷草转氨酶(AST)降低,总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)降低,高密度脂蛋白胆固醇(HDL-C)升高;细胞质胞浆内核因子E2相关因子2(Nrf2)蛋白减少,总Kelch样环氧氯丙烷相关蛋白1(Keap1)减少,导致过氧化氢酶(CAT)、还原型谷胱甘肽(GSH)、超氧化物歧化酶(SOD)不同程度升高,丙二醛(MDA)降低;炎症相关蛋白诱导型一氧化氮合酶(INOS)、环氧合酶-2(COX-2)、核因子κB(NF-κB)均不同程度降低。相较于食用酒精,绵柔型酒样1#和绵柔型酒样2#一定程度上减轻了实验小鼠肝损伤程度,可能是其中的活性物质起到了关键性作用。Thirty C57BL/6J mice were randomly divided into edible alcohol group,Mianrou-flavor Baijiu samples 1#and 2#treatment groups.The same dose of 52%vol edible alcohol,52%vol Mianrou-flavor Baijiu samples 1#and 2#were given by intragastric administration.Compared with edible alcohol group,alanine transaminase(ALT)and aspartate aminotransferase(AST)decreased,total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)increased in Mianrou-flavor Baijiu sample groups of mice;Cytoplasmic nuclear factor E2-related factor 2(Nrf2)protein decreased,total Kelch like epichlorohydrin associated protein 1(Keap1)decreased,resulting in catalase(CAT),reduced glutathione(GSH),peroxide dismutase(SOD)increased in different degrees,and malondialdehyde(MDA)decreased.Inflammation related protein-induced nitric oxide synthase(INOS),cyclooxygenase-2(COX-2),the nuclear factorκB(NF-κB)decreased in different degrees.Compared with edible alcohol,Mianrou-flavor Baijiu samples 1#and 2#reduced the degree of liver damage in experimental mice to a certain extent,which may be the active substances played a key role.

关 键 词：绵柔型白酒 肝损伤 氧化应激 细胞因子 

分 类 号：TS262.3[轻工技术与工程—发酵工程]