Mortalin/Hspa9 involvement and therapeutic perspective in Parkinson's disease  

作　　者：Baptiste Texier Morgane Prime Djamaa Atamena Pascale Belenguer Marion Szelechowski 

机构地区：[1]Toulouse Institute for Infectious and Inflammatory Diseases(INFINITY),UniversitéToulouse,CNRS,Inserm,UPS,Toulouse,France [2]Centre de Recherches sur la Cognition Animale(CRCA),Centre de Biologie Intégrative(CBI),Universitéde Toulouse,CNRS,UPS,Toulouse,France

出　　处：《Neural Regeneration Research》2023年第2期293-298,共6页中国神经再生研究（英文版）

摘　　要：By controlling the proper folding of proteins imported into mitochondria and ensuring crosstalk between the reticulum and mitochondria to modulate intra cellular calcium fluxes.Mortalin is a chaperone protein that plays crucial roles in neuronal homeostasis and activity.Howeve r,its expression and stability are strongly modified in response to cellular stresses,in particular upon alte red oxidative conditions during neurodegeneration.Here,we report and discuss the abundant literature that has highlighted its contribution to the pathophysiology of Parkinson's disease,as well as its therapeutic and prognostic potential in this still incurable pathology.

关 键 词：CHAPERONE Hspa9 MITOCHONDRIA Mortalin NEURODEGENERATION oxidative stress Parkinson's disease prognostic and therapeutic potential 

分 类 号：R742.5[医药卫生—神经病学与精神病学]