Anti-inflammatory effect of miR-125a-5p on experimental optic neuritis by promoting the differentiation of Treg cells  

作　　者：Jia-Lin Zhan Yan-Ling Huang Qiao-Wen Liang Xiao-Sheng Qu Zi-Mei Dong Yi Du Wen-Jing Luo 

机构地区：[1]Department of Ophthalmology,the First Affiliated Hospital of Guangxi Medical University,Nanning,Guangxi Zhuang Autonomous Region,China [2]National Engineering Laboratory of Southwest Endangered Medicinal Resources Development,Guangxi Botanical Garden of Medicinal Plants,Nanning,Guangxi Zhuang Autonomous Region,China [3]Department of Neurology,the People’s Hospital of Chuxiong Yi Autonomous Prefecture,Chuxiong Yi Autonomous Prefecture,Yunnan Province,China [4]Department of Neurology,the First Affiliated Hospital of Guangxi Medical University,Nanning,Guangxi Zhuang Autonomous Region,China

出　　处：《Neural Regeneration Research》2023年第2期451-455,共5页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.81560162;the Guangxi Natural Science Foundation of China,No.2018GXNSFAA050052(both YD)。

摘　　要：Methylprednisolone pulse treatment is currently used fo r optic neuritis.It can speed visual recovery,but does not improve the ultimate visual outcomes.Recent studies have repo rted that miR-125 a-5 p has immunomodulatory effects on autoimmune diseases.However,it remains unclear whether miR-125 a-5 p has effects on optic neuritis.In this study,we used adeno-associated virus to overexpress or silence miR-125 a-5 p in mice.We found that silencing miR-125 a-5 p increased the latency of visual evoked potential and aggravated inflammation of the optic nerve.Ove rexpression of miR-125 a-5 p suppressed inflammation of the optic nerve,protected retinal ganglion cells,and increased the percentage of Treg cells.Our findings show that miR-125 a-5 p exhibits anti-inflammatory effects through promoting the diffe rentiation of Treg cells.

关 键 词：AQUAPORIN-4 CORTICOSTEROIDS inflammation microRNA NEUROPROTECTION OLIGODENDROCYTE optic neuropathy regulatory T cells Th17 cell visual field defect 

分 类 号：R741[医药卫生—神经病学与精神病学]