6’-O-咖啡酰基熊果苷对Ⅰ型糖尿病的保护作用  

The Protective Effect of 6’-O-caffeoylarbutin on Type I Diabetes

作　　者：陶俊葓 何舒悦 孔令朋 程桂广[1] Tao Junhong;He Shuyue;Kong Lingpeng;Cheng Guiguang(Faculty of Agriculture and Food,Kunming University of Science and Technology,Kunming 650500)

机构地区：[1]昆明理工大学农业与食品学院,昆明650500

出　　处：《中国食品学报》2022年第6期168-176,共9页Journal of Chinese Institute Of Food Science and Technology

基　　金：云南省重大自然科学基金项目(2019ZF010)。

摘　　要：探讨6’-O-咖啡酰基熊果苷(CA)对Ⅰ型糖尿病小鼠的血糖干预和对脏器的保护作用。方法:小鼠被注射四氧嘧啶建立Ⅰ型糖尿病模型;建模成功后,小鼠被随机分为空白对照组、模型组、阳性对照组、6’-O-咖啡酰基熊果苷低剂量组(100 mg/kg/d bw)、6’-O-咖啡酰基熊果苷高剂量组(200 mg/kg/d bw)。以6’-O-咖啡酰基熊果苷为受试药进行灌胃干预,连续给药4周后,对各组小鼠耐糖量、脏器指数、血清指标、肝脏和肾脏组织指标进行测定和脏器组织病理学检测。结果表明:6'-O-咖啡酰基熊果苷能够降低Ⅰ型糖尿病小鼠血清中TC、TG、NEFA和LDL-C含量,升高HDL-C和NEFA含量;提高肝脏组织中SOD、CAT、GSH-Px活力,降低MDA含量、ALT活力、AKP活力和肾脏组织中BUN的含量;降低肾脏、肝脏和胰腺组织病理的损伤。结论:6’-O-咖啡酰基熊果苷有一定的降血糖效果,对Ⅰ型糖尿病小鼠肝脏、肾脏、胰腺有一定的保护作用。In order to determine 6'-O-caffeoylarbutin protection of type I diabetes in mice,mice were injected alloxan drugs to create type I diabetes model,and diabetic mice were also treated with 6'-O-caffeoylarbutin.Mice were randomly divided into 5 groups:normal control group,model group,positive control group,6'-O-caffeoylarbutin low-dose group(100 mg/kg/d bw),and 6'-O-caffeoylarbutin high-dose group(200mg/kg/d bw).After continuous intragastric administration for 4 weeks,glucose tolerance,organ index,serum index,liver and kidney indexes of mice in each group were measured,and pathological examination of pancreas,liver and kidney tissues was conducted.The results showed that the 6'-O-caffeoylarbutin can reduce type I diabetes mice serum total cholesterol,triglycerides,free fatty acid and low density lipoprotein cholesterol,high-density lipoprotein cholesterol and insulin levels.6'-O-caffeoylarbutin can also increase the activity of superoxide dismutase,catalase and glutathione peroxidase in liver tissue,and reduce the content of malondialdehyde,alanine aminotransferase,alkaline phosphatase and urea nitrogen in kidney tissue.Conclusion:6'-O-caffeoylarbutin has a certain hypoglycemic effect,and can effectively alleviate the injury of liver,kidney,pancreas and other tissues in type I diabetes mice.

关 键 词：6’-O-咖啡酰基熊果苷 降血糖 Ⅰ型糖尿病 

分 类 号：TS201.4[轻工技术与工程—食品科学]