Recent development on COX-2 inhibitors as promising anti-inflammatory agents:The past 10 years  

作　　者：Zhiran Ju Menglan Li Junde Xu Daniel C.Howell Zhiyun Li Fen-Er Chen 

机构地区：[1]Institute of Pharmaceutical Science and Technology,Zhejiang University of Technology,Hangzhou 310014,China [2]Engineering Center of Catalysis and Synthesis for Chiral Molecules,Fudan University,Shanghai 200433,China [3]Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs,Shanghai 200433,China [4]Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals,Zhejiang University of Technology,Hangzhou 310014,China

出　　处：《Acta Pharmaceutica Sinica B》2022年第6期2790-2807,共18页药学学报（英文版）

摘　　要：Cyclooxygenases play a vital role in inflammation and are responsible for the production of prostaglandins.Two cyclooxygenases are described,the constitutive cyclooxygenase-1 and the inducible cyclooxygenase-2,for which the target inhibitors are the non-steroidal anti-inflammatory drugs(NSAIDs).Prostaglandins are a class of lipid compounds that mediate acute and chronic inflammation.NSAIDs are the most frequent choices for treatment of inflammation.Nevertheless,currently used anti-inflammatory drugs have become associated with a variety of adverse effects which lead to diminished output even market withdrawal.Recently,more studies have been carried out on searching novel selective COX-2 inhibitors with safety profiles.In this review,we highlight the various structural classes of organic and natural scaffolds with efficient COX-2 inhibitory activity reported during 2011-2021.It will be valuable for pharmaceutical scientists to read up on the current chemicals to pave the way for subsequent research.

关 键 词：INFLAMMATION CYCLOOXYGENASE PROSTAGLANDINS Adverse effects COX-2 inhibitors 

分 类 号：R914[医药卫生—药物化学]