Anabolic androgenic steroid-induced liver injury:An update  

作　　者：Ana Petrovic Sonja Vukadin Renata Sikora Kristina Bojanic Robert Smolic Davor Plavec George Y Wu Martina Smolic 

机构地区：[1]Department of Pharmacology and Biochemistry,Faculty of Dental Medicine and Health Osijek,J.J.Strossmayer University of Osijek,Osijek 31000,Croatia [2]Department of Pharmacology,Faculty of Medicine Osijek,J.J.Strossmayer University of Osijek,Osijek 31000,Croatia [3]Department of Dental Medicine,Faculty of Dental Medicine and Health Osijek,J.J.Strossmayer University of Osijek,Osijek 31000,Croatia [4]Department of Dental Medicine,Health Center Osijek-Baranja County,Osijek 31000,Croatia [5]Department of Otorhinolaryngology,Neurosurgery and Radiology,Faculty of Dental Medicine and Health Osijek,J.J.Strossmayer University of Osijek,Osijek 31000,Croatia [6]Department of Biophysics and Radiology,Faculty of Medicine Osijek,J.J.Strossmayer University of Osijek,Osijek 31000,Croatia [7]Department of Radiology,Health Center Osijek-Baranja County,Osijek 31000,Croatia [8]Research Department,Srebrnjak Children's Hospital,Zagreb 10000,Croatia [9]Department of Medicine,Division of Gastrenterology/Hepatology,University of Connecticut Health Center,Farmington,CT 06030,United States

出　　处：《World Journal of Gastroenterology》2022年第26期3071-3080,共10页世界胃肠病学杂志（英文版）

摘　　要：Anabolic androgenic steroids(AASs)are a group of molecules including endogenous testosterone and synthetic derivatives that have both androgenic and anabolic effects.These properties make them therapeutically beneficial in medical conditions such as hypogonadism.However,they are commonly bought illegally and misused for their anabolic,skeletal muscle building,and performanceenhancing effects.Supraphysiologic and long-term use of AASs affects all organs,leading to cardiovascular,neurological,endocrine,gastrointestinal,renal,and hematologic disorders.Hepatotoxicity is one of the major concerns regarding AASs treatment and abuse.Testosterone and its derivatives have been most often shown to induce a specific form of cholestasis,peliosis hepatis,and hepatic benign and malignant tumors.It is currently believed that mechanisms of pathogenesis of these disorders include disturbance of antioxidative factors,upregulation of bile acid synthesis,and induction of hepatocyte hyperplasia.Most toxicity cases are treated with supportive measures and liver function normalizes with discontinuation of AAS.However,some long-term consequences are irreversible.AAS-induced liver injury should be taken in consideration in patients with liver disorders,especially with the increasing unintentional ingestion of supplements containing AAS.In this paper,we review the most current knowledge about AAS-associated adverse effects on the liver,and their clinical presentations,prevalence,and pathophysiological mechanisms.

关 键 词：ANDROGENS STEROIDS CHOLESTASIS FIBROSIS Liver Chemical and drug induced liver injury 

分 类 号：R575[医药卫生—消化系统]