Possible mechanisms of bidirectional nuclear transport during neuronal migration  

作　　者：CHUYING ZHOU MINEKO KENGAKU 

机构地区：[1]Graduate School of Biostudies,Kyoto University,Kyoto,606-8501,Japan [2]Institute for Integrated Cell-Material Sciences(WPI-iCeMS),Kyoto University,Kyoto,606-8501,Japan

出　　处：《BIOCELL》2022年第11期2357-2361,共5页生物细胞（英文）

基　　金：This work was supported by KAKENHI grant from the Japan Society for the Promotion of Science(JSPS)to MK(20H00483).CZ was supported by the Otsuka Toshimi Scholarship Foundation.

摘　　要：Neuronal migration is a fundamental process of mammalian brain development.In migrating neurons,the nuclear membrane protein Nesprin-2 has been shown to serve as an adaptor to pull the nucleus along microtubule tracks.Current evidence has shown that Nesprin-2 binds to both the minus-end-directed motor dynein as well as the plus-end-directed motor kinesin.However,translocation of neuronal nucleus has long been thought to be primarily driven by dynein motors.Intriguing questions could be raised about the role of kinesin in nuclear transport and how the activities of opposing motors are coordinated through interactions with Nesprin.Combining evidence from recent studies,we propose that Nesprin-2 serves as a switchboard in mediating bidirectional neuronal nuclear movements.

关 键 词：Nesprin-2 NUCLEUS MICROTUBULES KINESIN DYNEIN 

分 类 号：O57[理学—粒子物理与原子核物理]