DYNEIN

作品数：35被引量：64H指数：5
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相关领域：生物学更多>>
相关作者：朱学良王晓梅鄢秀敏周天华张洋更多>>
相关机构：中国科学院上海生命科学研究院浙江大学汕头大学苏州大学更多>>
相关期刊：《Asian Journal of Andrology》《Frontiers of Medicine》《Science China(Life Sciences)》《Frontiers in Biology》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划高等学校学科创新引智计划北京市自然科学基金更多>>
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Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice被引量：1
《Frontiers of Medicine》2023年第5期957-971,共15页Rongchun Wang Danhui Yang Chaofeng Tu Cheng Lei Shuizi Ding Ting Guo Lin Wang Ying Liu Chenyang Lu Binyi Yang Shi Ouyang Ke Gong Zhiping Tan Yun Deng Yueqiu Tan Jie Qing Hong Luo 
supported by the National Natural Science Foundation of China (Nos.82070003,82100057,81900002,82101961,31970504,and 31772548);Natural Science Foundation of Hunan Province,China (Nos.2020JJ5805 and 2021JJ30943);Xiangya Clinical Big Data System Construction Project in Pulmonary Inflammatory Disease of Central South University;the National Key Clinical Specialty Construction Projects of China。
Primary ciliary dyskinesia(PCD)is a congenital,motile ciliopathy with pleiotropic symptoms.Although nearly 50 causative genes have been identified,they only account for approximately 70%of definitive PCD cases.Dynein ...
关键词：DNAH10 MICE motile cilia mutation primary ciliary dyskinesia 
DRC3 is an assembly adapter of the nexin-dynein regulatory complex functional components during spermatogenesis in humans and mice
《Signal Transduction and Targeted Therapy》2023年第2期351-354,共4页Shushu Zhou Shimin Yuan Jintao Zhang Lanlan Meng Xin Zhang Siyu Liu Guangxiu Lu Ge Lin Mingxi Liu Yue-Qiu Tan 
This work was supported by the National Key Research and Development Program of China(2022YFC2702702 to M.L.and 2022YFC2702604 to Y.T.);the National Natural Science Foundation of China(32270899 and 32070842 to M.L.,82101961,82171608,82201773 and 81971447 to Y.T.);the Natural Science Foundation of Jiangsu Province(BK20190081 to M.L.);Changsha Municipal Natural Science Foundation(kq2202493 to S.Y.).We sincerely appreciate Zhuang Xiao and Shuqin Zhao from State Key Laboratory of Reproductive Medicine,Nanjing Medical University,Chen Tan,Huan Zhang,Chaofeng Tu,Qinwei Zhou,Fei Meng,Qianjun Zhang,and Chunbo Xie from Reproductive and Genetic Hospital of CITIC-XIANGYA for their assistance in this study.
Dear Editor,Male subfertility,a multifactorial disease affecting~7%of the global male population,is usually caused by abnormalities in sperm flagella.The flagella and motile cilia have similar“9+2”axonemes and are e...
关键词：FERTILITY functional ASSEMBLY 
Possible mechanisms of bidirectional nuclear transport during neuronal migration
《BIOCELL》2022年第11期2357-2361,共5页CHUYING ZHOU MINEKO KENGAKU 
This work was supported by KAKENHI grant from the Japan Society for the Promotion of Science(JSPS)to MK(20H00483).CZ was supported by the Otsuka Toshimi Scholarship Foundation.
Neuronal migration is a fundamental process of mammalian brain development.In migrating neurons,the nuclear membrane protein Nesprin-2 has been shown to serve as an adaptor to pull the nucleus along microtubule tracks...
关键词：Nesprin-2 NUCLEUS MICROTUBULES KINESIN DYNEIN 
A recurrent homozygous missense mutation in CCDC103 causes asthenoteratozoospermia due to disorganized dynein arms被引量：1
《Asian Journal of Andrology》2022年第3期255-259,共5页Muhammad Zubair Ranjha Khan Ao Ma Uzma Hameed Mazhar Khan Tanveer Abbas Riaz Ahmad Jian-Teng Zhou Wasim Shah Ansar Hussain Nisar Ahmed Ihsan Khan Khalid Khan Yuan-Wei Zhang Huan Zhang Li-Min Wu Qing-Hua Shi 
supported by the National Natural Science Foundation of China(No.81971446).
Asthenoteratozoospermia is one of the most severe types of qualitative sperm defects.Most cases are due to mutations in genes encoding the components of sperm flagella,which have an ultrastructure similar to that of m...
关键词：asthenoteratozoospermia CCDC103 dynein arms male infertility 
电针“百会”“涌泉”对6月龄APP/PS1双转基因小鼠行为学及海马Dynein、CTSD水平影响的研究被引量：3
《针灸临床杂志》2022年第4期67-73,共7页张洋 谭韵湘 高誉珊 杨晓坤 栗晨璐 薛卫国 
国家自然科学基金面上项目,编号:81273826;北京市自然科学基金资助项目面上项目,编号:7202117。
目的:从细胞内β-淀粉样蛋白(Aβ)及自噬溶酶体角度探讨电针干预阿尔茨海默病(AD)的作用机制。方法:将20只6月龄雄性APP/PS1双转基因小鼠随机分为电针组和模型组;10只6月龄雄性C57BL/6野生小鼠作为空白对照组。电针组针刺“百会”“涌...
关键词：阿尔茨海默病 APP/PS1双转基因小鼠 自噬 DYNEIN CTSD 
地塞米松对体外培养胎鼠大脑皮质神经元胞浆Dynein重链和Dynactin表达的影响
《中国当代儿科杂志》2021年第6期639-644,共6页程琳 谢紫云 里健 薄涛 
国家自然科学基金(81671506)。
目的研究地塞米松(dexamethasone,DEX)对体外培养胎鼠大脑皮质神经元胞浆动力蛋白Dynein重链(Dynein heavy chain,DHC)和Dynactin表达的影响。方法体外培养原代胎鼠大脑皮质神经元细胞,制作DEX干预细胞模型。依据DEX终浓度不同,分为对照...
关键词：脑发育 地塞米松 Dynein重链 Dynactin 大鼠 神经元 
Axonemal Dynein DNAH5 is Required for Sound Sensation in Drosophila Larvae
《Neuroscience Bulletin》2021年第4期523-534,共12页Bingxue Li Songling Li Zhiqiang Yan 
the National Key R&D Program of China Project(2017YFA0103900 and 2016YFA0502800);the National Natural Science Foundation of China(31571083 and 31970931);the Program for Professor of Special Appointment(Eastern Scholar of Shanghai,TP2014008);the Shanghai Municipal Science and Technology Major Project(2017SHZDZX01 and 2018SHZDZX01);ZJLab,and the Shanghai Rising-Star Program(14QA1400800)。
Chordotonal neurons are responsible for sound sensation in Drosophila.However,little is known about how they respond to sound with high sensitivity.Using genetic labeling,we found one of the Drosophila axonemal dynein...
关键词：Chordotonal neuron CILIA DYNEIN Drosophila larvae Sound sensation 
Novel compound heterozygous variants in dynein axonemal heavy chain 17 cause asthenoteratospermia with sperm flagellar defects被引量：2
《Journal of Genetics and Genomics》2020年第11期713-717,共5页Bing Song Chunyu Liu Yang Gao Jordan Lee Marley Weiyu Li Xiaoqin Ni Wangjie Liu Yujie Chen Jiajia Wang Chao Wang Ping Zhou Zhaolian Wei Xiaojin He Feng Zhang Yunxia Cao 
supported by the National Natural Science Foundation of China(81971441,31625015,and 31521003);Foundation of the Education Department of Anhui Province(KJ2019A0286);Key R&D program of Anhui Province(202004j07020032)
The axoneme of the human sperm has a very similar ultrastructure to motile cilia,the"9+2"structure,comprising nine peripheral double microtubules plus two central pairs(Nicastro et al.,2006;Ishikawa,2017).A proteomics...
关键词：al. COMPOUND ULTRASTRUCTURE 
Chlamydomonas WDR92 in association with R2TP-like complex and multiple DNAAFs to regulate ciliary dynein preassembly
《Journal of Molecular Cell Biology》2019年第9期770-780,共11页Guang Liu Limei Wang Junmin Pan 
the National Key R&D Program of China(2017YFA0503500);the National Natural Science Foundation of China(31330044 and 31671387)to J.P.
The motility of cilia or eukaryotic flagella is powered by the axonemal dyneins,which are preassembled in the cytoplasm by proteins termed dynein arm assembly factors(DNAAFs)before being transported to and assembled o...
关键词：CILIA MOTILITY DYNEIN arm assembly factors R2TP COMPLEX WDR92 CHLAMYDOMONAS 
Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat被引量：2
《Journal of Molecular Cell Biology》2019年第5期383-394,共12页Yirong Zhang Yawen Chen Jianqun Zheng Juan Wang Shichao Duan Wei Zhang Xiumin Yan Xueliang Zhu 
the National Natural Science Foundation of China (NSFC;31330045);the National Key R&D Program of China (2017YFA0503500);Chinese Academy of Sciences (XDBl9020000);NSFC (31471323) to X.Y.
Motile cilia and flagella are microtubule-based organelles important for cell locomotion and extracellular liquid flow through beating. Although axonenal dyneins that drive ciliary beat have been extensively studied i...
关键词：axonemal DYNEIN Dynein-f IC138 MOTILE CILIUM primary CILIARY DYSKINESIA Wdr78 Dnah2 
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