Theoretical development and mechanism research of evodiamine's antitumor effect  

作　　者：Li-Ping Liu Tian-Xiang Lei De-Liang Li Feng Li Ping-Xiang Li Ke-Li Ge Cheng-Shan Ma 

机构地区：[1]Medicine College,Qingdao University,Qingdao 266023,China [2]Linyi People's Hospital,Linyi 276000,China [3]Affiliated Hospital of Qingdao University,Qingdao 266023,China [4]Zibo Bashan Wanjie Hospital,Zibo 255213,China [5]Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250000,China

出　　处：《Medical Theory and Hypothesis》2022年第3期21-26,共6页医学理论与假说

基　　金：Shandong Key R&D Program of Shandong Province(No.2017GSF218084);Qingdao Applied Basic Research Program(No.19-6-2-31-cg).

摘　　要：Evodiamine(EVO),one of the bioactive components of traditional Chinese medicine,has been widely concerned for its anti-tumor properties in recent years.In this review,the anti-tumor mechanism of EVO was reviewed from the aspects of inducing tumor cell apoptosis(internal pathway,external pathway and other pathways),inducing autophagy,inhibiting tumor stem cells,inhibiting cell proliferation and migration,inhibiting peripheral vascular proliferation,and recent research progress of EVO anti-tumor drugs.

关 键 词：EVODIAMINE ANTI-TUMOR APOPTOSIS AUTOPHAGY cancer stem cells 

分 类 号：R73[医药卫生—肿瘤]