食源性抗炎活性肽的研究进展  

Research Progress on Food Derived Anti-inflammatory Peptides

作　　者：傅丽娟 邢路娟 张万刚[1] Fu Lijuan;Xing Lujuan;Zhang Wangang(National Center of Meat Quality and Safety Control,College of Food Science Technology,Nanjing Agricultural University,Nanjing 210095)

机构地区：[1]南京农业大学食品科技学院,国家肉品质量安全与工程技术研究中心,南京210095

出　　处：《中国食品学报》2022年第8期343-352,共10页Journal of Chinese Institute Of Food Science and Technology

基　　金：国家自然科学基金青年科学基金项目(32001720)。

摘　　要：生物活性肽是蛋白质降解后产生的具有一定生理调节功能的多肽,其生物学功能体现在抗菌、抗氧化、抗炎、降血压、免疫调节等方面。其中,抗炎活性肽可通过调控细胞因子的分泌、炎性介质的合成参与机体炎症反应,从而发挥生理调节功能。慢性炎症与心血管、糖尿病等疾病的发生有直接联系。与传统抗炎药物相比,食源性抗炎活性肽具有安全、无副作用的特点,可为预防机体炎症提供新的方法。本文综述食源性抗炎活性肽的制备、炎症调节及其参与的信号通路,以期为食源性抗炎活性肽类的科学研究及产品研发提供参考。Bioactive peptide which is produced by protein degradation has certain physiological regulation function,and its biological function is reflected in antibacterial,antioxidant,anti-inflammatory,antihypertensive,immune regulation and others.In specially,Anti-inflammatory peptides can participate in the body's inflammatory response by regulating the secretion of cytokines and the synthesis of inflammatory mediator,which would play the physiologically regulatory function.Chronic inflammation is directly related to cardiovascular disease,diabetes and other metabolic diseases.Compared with anti-inflammatory drugs,food derived anti-inflammatory peptides have the characteristics of safety without side effects,which can provide a new strategy for the prevention of inflammation.Therefore,this review focused on the extraction,inflammatory regulation and signal pathways of food derived anti-inflammatory peptides.Hopefully,this review could supply the theory support on the scientific research and the product development of food derived anti-inflammatory peptides.

关 键 词：抗炎 生物活性肽 食物蛋白 炎症反应 调节通路 

分 类 号：TS201.2[轻工技术与工程—食品科学]