Intestinal epithelial plasticity and regeneration via cell dedifferentiation  

作　　者：Yuan Liu Ye-Guang Chen 

机构地区：[1]The State Key Laboratory of Membrane Biology,Tsinghua-Peking Center for Life Sciences,School of Life Sciences,Tsinghua University,Beijing 100084,China

出　　处：《Cell Regeneration》2020年第1期144-154,共11页细胞再生（英文）

基　　金：The research in the Chen’s lab is supported by the grants from the National Natural Science Foundation of China(31988101 and 31730056);the National Key Research and Development Program of China(2017YFA0103601).

摘　　要：The intestinal epithelium possesses a great capacity of self-renewal under normal homeostatic conditions and of regeneration upon damages.The renewal and regenerative processes are driven by intestinal stem cells(ISCs),which reside at the base of crypts and are marked by Lgr5.As Lgr5^(+)ISCs undergo fast cycling and are vulnerable to damages,there must be other types of cells that can replenish the lost Lgr5^(+)ISCs and then regenerate the damage epithelium.In addition to Lgr5^(+)ISCs,quiescent ISCs at the+4 position in the crypt have been proposed to convert to Lgr5^(+)ISCs during regeneration.However,this“reserve stem cell”model still remains controversial.Different from the traditional view of a hierarchical organization of the intestinal epithelium,recent works support the dynamic“dedifferentiation”model,in which various cell types within the epithelium can de-differentiate to revert to the stem cell state and then regenerate the epithelium upon tissue injury.Here,we provide an overview of the cell identity and features of two distinct models and discuss the possible mechanisms underlying the intestinal epithelial plasticity.

关 键 词：INTESTINE Stem cells REGENERATION DEDIFFERENTIATION PLASTICITY QUIESCENCE 

分 类 号：U23[交通运输工程—道路与铁道工程]