Development of Epstein-Barr virus-associated gastric cancer:Infection,inflammation,and oncogenesis  

作　　者：Hisashi Iizasa Andy Visi Kartika Sintayehu Fekadu Shunpei Okada Daichi Onomura Afifah Fatimah Azzahra Ahmad Wadi Mosammat Mahmuda Khatun Thin Myat Moe Jun Nishikawa Hironori Yoshiyama 

机构地区：[1]Department of Microbiology,Shimane University Faculty of Medicine,Izumo 693-8501,Shimane,Japan [2]Faculty of Medicine,Muslim University of Indonesia,Makassar 90231,Indonesia [3]Department of Medical Microbiology and Parasitology,Hawassa University,College of Medicine and Health Science,Hawassa 1560,Ethiopia [4]Faculty of Laboratory Science,Yamaguchi University Graduate School of Medicine,Ube 755-8505,Japan

出　　处：《World Journal of Gastroenterology》2022年第44期6249-6257,共9页世界胃肠病学杂志（英文版）

基　　金：Supported by Grant-in-Aid for Scientific Research From the Ministry of Education,Culture,Science and Technology of Japan,No.21K07054(Hironori Yoshiyama)and No.22K07101(Hisashi Iizasa).

摘　　要：Epstein-Barr virus(EBV)-associated gastric cancer(EBVaGC)cells originate from a single-cell clone infected with EBV.However,more than 95%of patients with gastric cancer have a history of Helicobacter pylori(H.pylori)infection,and H.pylori is a major causative agent of gastric cancer.Therefore,it has long been argued that H.pylori infection may affect the development of EBVaGC,a subtype of gastric cancer.Atrophic gastrointestinal inflammation,a symptom of H.pylori infection,is observed in the gastric mucosa of EBVaGC.Therefore,it remains unclear whether H.pylori infection is a cofactor for gastric carcinogenesis caused by EBV infection or whether H.pylori and EBV infections act independently on gastric cancer formation.It has been reported that EBV infection assists in the oncogenesis of gastric cancer caused by H.pylori infection.In contrast,several studies have reported that H.pylori infection accelerates tumorigenesis initiated by EBV infection.By reviewing both clinical epidemiological and experimental data,we reorganized the role of H.pylori and EBV infections in gastric cancer formation.

关 键 词：Helicobacter pylori Epstein-Barr virus Epstein-Barr virus-associated gastric cancer CORECEPTOR INFLAMMATION ONCOGENESIS 

分 类 号：R735.2[医药卫生—肿瘤]