CORECEPTOR

作品数:10被引量:32H指数:4
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相关领域:医药卫生生物学更多>>
相关作者:曹阳裴钢蒋华良罗小民嵇汝运更多>>
相关机构:中国科学院苏州大学中国科学院上海生命科学研究院复旦大学更多>>
相关期刊:《Chinese Journal of Sexually Transmitted Infections》《Cellular & Molecular Immunology》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》更多>>
相关基金:国家自然科学基金更多>>
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Development of Epstein-Barr virus-associated gastric cancer:Infection,inflammation,and oncogenesis被引量:8
《World Journal of Gastroenterology》2022年第44期6249-6257,共9页Hisashi Iizasa Andy Visi Kartika Sintayehu Fekadu Shunpei Okada Daichi Onomura Afifah Fatimah Azzahra Ahmad Wadi Mosammat Mahmuda Khatun Thin Myat Moe Jun Nishikawa Hironori Yoshiyama 
Supported by Grant-in-Aid for Scientific Research From the Ministry of Education,Culture,Science and Technology of Japan,No.21K07054(Hironori Yoshiyama)and No.22K07101(Hisashi Iizasa).
Epstein-Barr virus(EBV)-associated gastric cancer(EBVaGC)cells originate from a single-cell clone infected with EBV.However,more than 95%of patients with gastric cancer have a history of Helicobacter pylori(H.pylori)i...
关键词:Helicobacter pylori Epstein-Barr virus Epstein-Barr virus-associated gastric cancer CORECEPTOR INFLAMMATION ONCOGENESIS 
Mex3B: a coreceptor to present dsRNA to TLR3被引量:1
《Cell Research》2016年第4期391-392,共2页Shu Zhu, Geng Wang, Xuqiu Lei Richard A Flavell 
Toll-Like Receptors (TLRs) play critical roles in the early innate im- mune response to invading pathogens by sensing microorganisms; a num- ber of accessory molecules have been shown to assist microbial recognition...
关键词:DSRNA Toll样受体 微生物入侵 双链RNA 通过检测 水解处理 病原体 TLR 
The RNA-binding protein Mex3B is a coreceptor of Toll- like receptor 3 in innate antiviral response被引量:12
《Cell Research》2016年第3期288-303,共16页Yan Yang Su-Yun Wang Zhe-Fu Huang Hong-Mei Zou Bing-Ru Yan Wei-Wei Luo Yan-Yi Wang 
Recognition of viral dsRNA by Toll-like receptor 3 (TLR3) leads to induction of interferons (IFNs) and proinflam- matory cytokines, and innate antiviral response. Here we identified the RNA-binding protein Mex3B a...
关键词:TLR3 Mex3B proteolytic processing dsRNA-binding activity 
Combinatorial Effects of SDF-1 and CCL3L1 Gene Variants and Susceptibility to HIV-1/AIDS in Indian Population
《Journal of Health Science》2015年第6期276-281,共6页Suhani H. Almal Anuroopa Gupta Harish Padh 
HIV-1 infection requires the expression of CD4+ molecules in colligation with C-C chemokine receptor type 5 (CCR5) and C-X-C chemokine receptor type 4 (CXCR4) as the major coreceptors. The role of SNP in 3' untr...
关键词:CCL3L1 CORECEPTOR gene copy number HIV-1 SDF-1 SNP. 
Differential remodeling of a T-cell transcriptome following CD8- versus CD3-induced signaling
《Cell Research》2008年第6期641-648,共8页S Hussain I Abidi Tao Dong Mai T Vuong Vattipally B Sreenu Sarah L Rowland-Jones Edward J Evans Simon J Davis 
CD8 engagement with class I major histocompatibility antigens greatly enhances T-cell activation, but it is not clear how this is achieved. We address the question of whether or not the antibody-mediated ligation of C...
关键词:receptor triggering signaling CD8 CORECEPTOR SAGE expression analysis 
R5 to X4 coreceptor switch of human immunodeficiency virus type 1B' and B'/C recombinant subtype isolates in China被引量:7
《Chinese Medical Journal》2007年第6期522-525,共4页GUO Yan-fang MA Li-ying YUAN Lin WANG Shu-hua SUN Jian-ping XU Wei-si Xu Jian-qing XING Hui HONG Kun-xue ZHANG Xiao-yan RUAN Yu-hua ZHANG Yao-xin SHAO Yi-ming 
This study was supported by the grants from the Ministry of Science and Technology of People's Republic of China(No.2005CB523103 and No.2005CB522903);the US NIH grants(No.U19AIS1915-03)
The chemokine receptors CCR5 and CXCR4 play an important role as coreceptors for human immunodeficiency virus type 1 (HIV-1) entring into cells. HIV-1 isolates can be distinguished by the chemokine coreceptors. Nons...
关键词:HIV-1 B '/C recombinant viruses subtype B' coreceptor switch 
Novel SLA-DR Alleles of Three Chinese Pig Strains and the Related Function in Human T Cell Response被引量:5
《Cellular & Molecular Immunology》2004年第3期212-218,共7页FuxiangChen JinXie YunZhou NingliLi Kuang-YenChou 
supported by the grants from the National Natural Science Foundation of China(39993430-2);the National 863 Foundation(2003AA205009);the Foundation of Shanghai Sci-Tech Committee(04JC14085).
To elucidate the structures of SLA-DR(swine leukocyte antigen DR)genes of three Chinese pig strains (Gz,Bm and Yn),the SLA-DRA and SLA-DRB cDNA were amplified by RT-PCR and subjected to determine the sequences.The who...
关键词:MHC-DR SLA Chinese pig strain CD4 coreceptor XENOTRANSPLANTATION 
Construction and expression of the bicistronic expression vector with RANTES and SDF-1 genes
《Journal of Medical Colleges of PLA(China)》2003年第6期369-372,共4页张颖 白雪帆 李谨革 黄长形 孙永涛 聂青和 王九平 
NationalNaturalScienceFoundationofChina(No .39970 6 95 )
Objective: To construct bicistronic expression vector with RANTES and SDF-1 genes, the ligands of HIV-1 principal coreceptors, and identify its expression. Methods: RANTES-KDEL was amplified from plasmid pCMV-R-K by P...
关键词:HIV-1 CORECEPTOR CHEMOKINE bicistronic expression vector TRANSFECTION indirect immumofluorescence radioimmunoprecipitation 
Characterization of CCR5Δ32、CCR2b-641、CX3CR1-2491280M and SDF1-3'A Allelic Polymorphisms in the Chinese Uygur Population
《Chinese Journal of Sexually Transmitted Infections》2002年第2期7-11,共5页刘明旭 王福生 金磊 洪卫国 雷周云 张冰 候静 张战平 唐纯军 
This project was funded by the National Natural Science Foundation of China(No:397706830)
Objective: Allelic polymorphisms of CCR5△32CCR2b-64I,CX3CR1-2491280M and SDF1-3'A associatedwith HIV-1 infection and disease progression wereinvestigated in indigenous Uygur populations from theXinjiang Uygur Autonom...
关键词:HIV-1 coreceptor Allelic polymorphism Gene mutation PCR-RFLP 
Building three-dimensional structures of HIV-1 coreceptor CCR5 and its interaction with antagonist TAK779 by comparative molecular modeling
《Acta Pharmacologica Sinica》2000年第6期43-50,共8页黄小琴 蒋华良 罗小民 陈凯先 嵇汝运 曹阳 裴钢 
Project supported by the Key Program of National Natural Science Foundation of China (Grants 29790123 and 29725203)
AIM: To study the mechanism of interaction of CCR5 receptor with its antagonist TAK779. METHODS: Comparative molecular modeling has been used to develop the 3D-structural models of CCR5 receptor and its complex with T...
关键词:TAK 779 CCR5 receptor molecular structure HIV-1 computer aided design 
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