Supported by Grant-in-Aid for Scientific Research From the Ministry of Education,Culture,Science and Technology of Japan,No.21K07054(Hironori Yoshiyama)and No.22K07101(Hisashi Iizasa).
Epstein-Barr virus(EBV)-associated gastric cancer(EBVaGC)cells originate from a single-cell clone infected with EBV.However,more than 95%of patients with gastric cancer have a history of Helicobacter pylori(H.pylori)i...
Toll-Like Receptors (TLRs) play critical roles in the early innate im- mune response to invading pathogens by sensing microorganisms; a num- ber of accessory molecules have been shown to assist microbial recognition...
Recognition of viral dsRNA by Toll-like receptor 3 (TLR3) leads to induction of interferons (IFNs) and proinflam- matory cytokines, and innate antiviral response. Here we identified the RNA-binding protein Mex3B a...
HIV-1 infection requires the expression of CD4+ molecules in colligation with C-C chemokine receptor type 5 (CCR5) and C-X-C chemokine receptor type 4 (CXCR4) as the major coreceptors. The role of SNP in 3' untr...
CD8 engagement with class I major histocompatibility antigens greatly enhances T-cell activation, but it is not clear how this is achieved. We address the question of whether or not the antibody-mediated ligation of C...
This study was supported by the grants from the Ministry of Science and Technology of People's Republic of China(No.2005CB523103 and No.2005CB522903);the US NIH grants(No.U19AIS1915-03)
The chemokine receptors CCR5 and CXCR4 play an important role as coreceptors for human immunodeficiency virus type 1 (HIV-1) entring into cells. HIV-1 isolates can be distinguished by the chemokine coreceptors. Nons...
supported by the grants from the National Natural Science Foundation of China(39993430-2);the National 863 Foundation(2003AA205009);the Foundation of Shanghai Sci-Tech Committee(04JC14085).
To elucidate the structures of SLA-DR(swine leukocyte antigen DR)genes of three Chinese pig strains (Gz,Bm and Yn),the SLA-DRA and SLA-DRB cDNA were amplified by RT-PCR and subjected to determine the sequences.The who...
Objective: To construct bicistronic expression vector with RANTES and SDF-1 genes, the ligands of HIV-1 principal coreceptors, and identify its expression. Methods: RANTES-KDEL was amplified from plasmid pCMV-R-K by P...
This project was funded by the National Natural Science Foundation of China(No:397706830)
Objective: Allelic polymorphisms of CCR5△32CCR2b-64I,CX3CR1-2491280M and SDF1-3'A associatedwith HIV-1 infection and disease progression wereinvestigated in indigenous Uygur populations from theXinjiang Uygur Autonom...
Project supported by the Key Program of National Natural Science Foundation of China (Grants 29790123 and 29725203)
AIM: To study the mechanism of interaction of CCR5 receptor with its antagonist TAK779. METHODS: Comparative molecular modeling has been used to develop the 3D-structural models of CCR5 receptor and its complex with T...