Scopoletin: Anticancer potential and mechanism of action  

作　　者：Lia Meilawati Rita Marleta Dewi Aprilia Nur Tasfiyati Abdi Wira Septama Lucia Dwi Antika 

机构地区：[1]Research Center for Pharmaceutical Ingredients and Traditional Medicine,National Research and Innovation Agency of Indonesia,Indonesia [2]Center for Biomedical Research,National Research and Innovation Agency of Indonesia,Indonesia [3]Research Center for Chemistry,National Research and Innovation Agency of Indonesia,Indonesia

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2023年第1期1-8,共8页亚太热带生物医学杂志（英文版）

摘　　要：Cancer is considered a leading cause of death worldwide due to its high morbidity and mortality rate.Conventional treatments for cancer therapy,such as chemotherapy,and radiotherapy,have been hampered by their side effects.Natural product-derived plants have been used for decades to treat diseases.Compared to conventional therapy,natural product has the potential to be effective against cancer with fewer side effects.This current review discussed the potential of scopoletin,a coumarin present in many edible plants,which elicits anticancer properties through multiple mechanisms,including modulating cell cycle arrest,inducing apoptosis,and regulating multiple signaling pathways.Understanding these mechanisms highlights the potential of scopoletin as a candidate for chemoprevention and chemotherapy.

关 键 词：SCOPOLETIN COUMARIN ANTICANCER Signaling pathway Cell cycle arrest APOPTOSIS 

分 类 号：R73[医药卫生—肿瘤]