Critical roles of non-coding RNAs in lifecycle and biology of Marek's disease herpesvirus  

作　　者：Man Teng Zhi-Jian Zhu Yongxiu Yao Venugopal Nair Gai-Ping Zhang Jun Luo 

机构地区：[1]Key Laboratory of Animal Immunology,Ministry of Agriculture and Rural Affairs of China&Henan Provincial Key Laboratory of Animal Immunology,Henan Academy of Agricultural Sciences,Zhengzhou 450002,China [2]UK-China Centre of Excellence for Research on Avian Diseases,Henan Academy of Agricultural Sciences,Zhengzhou 450002,China [3]School of Biological and Food Processing Engineering,Huanghuai University,Zhumadian 463000,China [4]The Pirbright Institute&UK-China Centre of Excellence for Research on Avian Diseases,Pirbright,Ash Road,Guildford,Surrey GU240NF,United Kingdom [5]International Joint Research Center of National Animal Immunology&College of Veterinary Medicine,Henan Agricultural University,Zhengzhou 450002,China [6]Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonoses,Yangzhou University,Yangzhou 225009,China [7]Key Laboratory of Animal Disease and Public Safety,College of Animal Science and Technology,Henan University of Science and Technology,Luoyang 471003,China

出　　处：《Science China(Life Sciences)》2023年第2期251-268,共18页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China(U21A20260);the Natural Science Foundation of Henan Province(212300410359);the Independent innovation project of Henan Academy of Agricultural Sciences(2022ZC65);the BBSRC Newton Fund Joint Centre Awards on“UK-China Centre of Excellence for Research on Avian Diseases”(BBS/OS/NW/000007)。

摘　　要：Over the past two decades, numerous non-coding RNAs(ncRNAs) have been identified in different biological systems including virology, especially in large DNA viruses such as herpesviruses. As a representative oncogenic alphaherpesvirus, Marek’s disease virus(MDV) causes an important immunosuppressive and rapid-onset neoplastic disease of poultry, namely Marek’s disease(MD). Vaccinations can efficiently prevent the onset of MD lymphomas and other clinical disease, often heralded as the first successful example of vaccination-based control of cancer. MDV infection is also an excellent model for research into virally-induced tumorigenesis. Recently, great progress has been made in understanding the functions of ncRNAs in MD biology.Herein, we give a review of the discovery and identification of MDV-encoded viral miRNAs, focusing on the genomics,expression profiles, and emerging critical roles of MDV-1 miRNAs as oncogenic miRNAs(oncomiRs) or tumor suppressor genes involved in the induction of MD lymphomas. We also described the involvements of host cellular miRNAs, lincRNAs, and circRNAs participating in MDV life cycle, pathogenesis, and/or tumorigenesis. The prospects, strategies, and new techniques such as the CRISPR/Cas9-based gene editing applicable for further investigation into the ncRNA-mediated regulatory mechanisms in MDV pathogenesis/oncogenesis were also discussed, together with the possibilities of future studies on antiviral therapy and the development of new efficient MD vaccines.

关 键 词：HERPESVIRUS MDV miRNA lincRNA circRNA CRISPR PATHOGENESIS ONCOGENESIS 

分 类 号：R730.2[医药卫生—肿瘤]