Epilepsy dynamics of an astrocyte-neuron model with ammonia intoxication  

作　　者：袁治轩 独盟盟 于羊羊 吴莹 Zhixuan Yuan;Mengmeng Du;Yangyang Yu;Ying Wu(State Key Laboratory for Strength and Vibration of Mechanical Structures,Shaanxi Engineering Laboratory for Vibration Control of Aerospace Structures,School of Aerospace Engineering,Xi'an Jiaotong University,Xi'an 710049,China;School of Mathematics and Data Science,Shaanxi University of Science and Technology,Xi'an 710000,China)

机构地区：[1]State Key Laboratory for Strength and Vibration of Mechanical Structures,Shaanxi Engineering Laboratory for Vibration Control of Aerospace Structures,School of Aerospace Engineering,Xi'an Jiaotong University,Xi'an 710049,China [2]School of Mathematics and Data Science,Shaanxi University of Science and Technology,Xi'an 710000,China

出　　处：《Chinese Physics B》2023年第2期128-135,共8页中国物理B（英文版）

基　　金：supported by the National Natural Science Foundation of China (Grant Nos. 12132012 and 11972275);the National Science Foundation for Young Scientists of China (Grant No. 12102240)。

摘　　要：Experimental records in the cerebral cortex indicate that ammonia injection can lead to seizures. Considering that astrocytes play a vital role in mediating the uptake and absorption of ammonium ions in the extracellular space of the cortical circuit, we constructed a new astrocyte neuron coupling model, which is composed of a neuron and its astrocytes connected through the extracellular space, taking into account of the influence of extracellular ammonium ions. The numerical results verified the previous experimental observation that obtained epileptic firing modes of neurons and postsynaptic GABA reversal potential depolarization triggered by ammonia injection. In addition, we also determined the concentration–response relationship between the ammonium ion concentration and the time of entering epilepsy and predicted the threshold of the ammonium ion concentration for the onset of epilepsy.

关 键 词：AMMONIA NEURON ASTROCYTE EPILEPSY 

分 类 号：R742.1[医药卫生—神经病学与精神病学]