Autophagy and autophagy-related molecules in neurodegenerative diseases  

作　　者：Changsong Dou Yu Zhang Ling Zhang Chuan Qin 

机构地区：[1]NHC Key Laboratory of Human Disease Comparative Medicine,Key Laboratory of Human Diseases Animal Model,Institute of Laboratory Animal Sciences,Comparative Medicine Center,Peking Union Medical College(PUMC),Chinese Academy of Medical Sciences(CAMS),Beijing,China [2]Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases Beijing,Comparative Medicine Center,Peking Union Medical College(PUMC),Chinese Academy of Medical Sciences(CAMS),Beijing,China

出　　处：《Animal Models and Experimental Medicine》2023年第1期10-17,共8页动物模型与实验医学（英文）

基　　金：National Natural Science Foundation of China grant(31970510,81941012);CAMS Innovation Fund for Medical Sciences(CIFMS)grant(2016-I2M-2-006,2016-I2M-1-010).

摘　　要：Autophagy is one of the degradation pathways to remove proteins or damaged or-ganelles in cells that plays an important role in neuroprotection.Different stages of autophagy are regulated by autophagy-related genes,and many molecules such as transcription factor EB(TFEB)are involved.The complete autophagy process plays an important role in maintaining the dynamic balance of autophagy and is crucial to the homeostasis of intracellular substance and energy metabolism.Autophagy balance is disrupted in neurodegenerative diseases,accounting for a variety of degeneration dis-orders.These impairments can be alleviated or treated by the regulation of autophagy through molecules such as TFEB.

关 键 词：AUTOPHAGY MITOPHAGY NEURODEGENERATIVE TFEB 

分 类 号：R74[医药卫生—神经病学与精神病学]