Immunomodulation:The next target of mesenchymal stem cell-derived exosomes in the context of ischemic stroke  

作　　者：Xiao-Qian Shan Yong-Yin Luo Jun Chang Jing-Jing Song Nan Hao Lan Zhao 

机构地区：[1]First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China [2]National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China

出　　处：《World Journal of Stem Cells》2023年第3期52-70,共19页世界干细胞杂志（英文版）（电子版）

基　　金：Supported by National Natural Science Foundation of China,No.82074533.

摘　　要：Ischemic stroke(IS)is the most prevalent form of brain disease,characterized by high morbidity,disability,and mortality.However,there is still a lack of ideal prevention and treatment measures in clinical practice.Notably,the trans-plantation therapy of mesenchymal stem cells(MSCs)has been a hot research topic in stroke.Nevertheless,there are risks associated with this cell therapy,including tumor formation,coagulation dysfunction,and vascular occlusion.Also,a growing number of studies suggest that the therapeutic effect after transplantation of MSCs is mainly attributed to MSC-derived exosomes(MSC-Exos).And this cell-free mediated therapy appears to circumvent many risks and difficulties when compared to cell therapy,and it may be the most promising new strategy for treating stroke as stem cell replacement therapy.Studies suggest that suppressing inflammation via modulation of the immune response is an additional treatment option for IS.Intriguingly,MSC-Exos mediates the inflam-matory immune response following IS by modulating the central nervous system,the peripheral immune system,and immunomodulatory molecules,thereby promoting neurofunctional recovery after stroke.Thus,this paper reviews the role,potential mechanisms,and therapeutic potential of MSC-Exos in post-IS inflammation in order to identify new research targets.

关 键 词：Mesenchymal stem cells EXOSOMES Ischemic stroke IMMUNOMODULATION INFLAMMATION Exosome therapy 

分 类 号：R743.3[医药卫生—神经病学与精神病学]