含有LG21乳酸菌酸奶对功能性消化不良人群症状改善的效果评价  

Evaluation of the effect of LG21 probiotic yogurt on symptom improvement in individuals with functional dyspepsia

作　　者：沈郁 高雷 苏丹婷[1] 赵栋[1] 王大宏 李芃 王畋 邹艳[1] 段云峰 章荣华[1] SHEN Yu;GAO Lei;SU Danting;ZHAO Dong;WANG Dahong;LI Fan;WANG Tian;ZOU Yan;DUAN Yunfeng;ZHANG Ronghua(Department of Nutrition and Food Safety,Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou 310051,China;China Nonprescription Medicines Association,Beijing 100080,China;Beijing Huayuan Biotechnology Research Institute,Beijing 100096,China)

机构地区：[1]浙江省疾病预防控制中心营养与食品安全所,浙江杭州310051 [2]中国非处方药物协会健康产品专业委员会,北京100080 [3]北京华元生物技术研究院,北京100096

出　　处：《健康研究》2023年第2期130-134,共5页Health Research

基　　金：浙江省疾控中心项目(2020-028-01)。

摘　　要：目的评价日常摄入含有益生菌(Lactobacillus gasseri OLL2716,LG21乳酸菌)的酸奶,对具有功能性消化不良症状人群的症状改善效果。方法从社区居民中筛选具有功能性消化不良症状的人群为研究对象,采用自身前后对照的设计,观察比较研究对象在饮用含有LG21乳酸菌的酸奶16周、180 g/d后功能性消化不良症状的改善情况。结果共纳入有功能性消化不良症状者235人,在饮用含有LG21乳酸菌的酸奶(110.12±5.13)天后,研究对象的消化道症状发生率(43.8%)低于干预前(100.0%),差异有统计学意义(χ^(2)=130.008,P<0.001)。干预前后,研究对象各项消化道症状得分差异均有统计学意义(均P<0.05),中上腹烧灼样不适及早饱不适感的平均改善率达79.7%、81.4%。结论含有LG21乳酸菌的酸奶可能可以改善功能性消化不良症状。Objective The aim of this study was to evaluate the effect of daily consumption of yogurt containing the beneficial bacteria Lactobacillus gasseri OLL2716(LG21 probiotic)on symptom improvement in individuals with functional dyspepsia.Methods Participants with functional dyspepsia were selected from a community population and included in a self-controlled design study.Changes in functional dyspepsia symptoms after 16 weeks and 180 g/d of LG21 probiotic yogurt consumption were observed and compared,and the effect of LG21 probiotic yogurt on improving functional dyspepsia symptoms was analyzed.Results A total of 235 individuals with functional dyspepsia were included.After 110.12±5.13 days of LG21 probiotic yogurt consumption,the incidence of digestive symptoms in the participants(43.8%)was significantly lower than before intervention(100.0%)(χ^(2)=130.008,P<0.001).Before and after intervention,there were statistically significant differences in the scores of various digestive symptoms(all P<0.05),with an average improvement rate of 79.7% and 81.4% for epigastric burning discomfort and early satiety,respectively.Conclusions Yogurt containing LG21 probiotic may be effective in improving symptoms of functional dyspepsia.

关 键 词：LG21乳酸菌 酸奶 功能性消化不良 胃部 膳食 

分 类 号：R154[医药卫生—营养与食品卫生学]