Cell models with inducible oncogenic translocations allow to evaluate the potential of drugs to favor secondary translocations  

作　　者：Anna Shmakova Nikolai Lomov Vladimir Viushkov Tatyana Tsfasman Yana Kozhevnikova Darina Sokolova Vadim Pokrovsky Marina Syrkina Diego Germini Mikhail Rubtsov Yegor Vassetzky 

机构地区：[1]UMR9018,UniversitéParis-Saclay,Centre national de la recherche scientifique,Gustave Roussy,Villejuif 94805,France [2]Koltzov Institute of Developmental Biology,Russian Academy of Sciences,Moscow 119334,Russia [3]Department of Molecular Biology,Faculty of Biology,Lomonosov Moscow State University,Leninskie Gory,Moscow 119991,Russia [4]Institute of Experimental Cardiology,National Medical Research Centre of Cardiology,Moscow 121552,Russia [5]Faculty of Medicine,Lomonosov Moscow State University,Moscow 119991,Russia [6]Laboratory of Combined Treatment,Blokhin Cancer Research Center,Moscow 115478,Russia [7]Department of Biochemistry,Peoples’Friendship University of Russia,Moscow 117198,Russia [8]Center of Genetics and Life Sciences,Sirius University of Science and Technology,Federal Territory Sirius,Sochi 354340,Russia [9]Department of Biochemistry,Center for Industrial Technologies and Entrepreneurship,Sechenov First Moscow State Medical University,Moscow 119991,Russia

出　　处：《Cancer Communications》2023年第1期154-158,共5页癌症通讯（英文）

基　　金：Cancéropole IdF,the Koltzov Institute of Developmental Biology,Russian Academy of Sciences Government basic research programs(0088-2021-0007);the Ministry of Science and Higher Education grants(075-15-2021-1075 to YV and 075-15-2021-1062 and 075-15-2021-1060 to MR);Russian Foundation for Basic Research(19-54-16002);the Interdisciplinary Scientific and Educational School of Moscow University≪Molecular Technologies of the Living Systems and Synthetic Biology≫to MR.AS was supported by the Travel Grant from Boehringer Ingelheim Fonds in 2018.

摘　　要：Dear Editor,Chromosomal translocations result from the interchange of geneticmaterial between non-homologous chromosomes.Chromosomal translocations are formed by erroneous repair of double-stranded breaks(DSBs)via non-homologous end joining(NHEJ)[1].Some genotoxic drugs produce DSBs and thus present a major risk factor for the development of oncogenic chromosomal translocations.The risk factors that interfere with translocationprone DSB repair,once DSBs are already formed,are obscure,and potential effects of drugs on translocation formation during this step have never been explored.

关 键 词：DRUGS POTENTIAL CHROMOSOMAL 

分 类 号：R730[医药卫生—肿瘤]