Diffuse midline glioma treated with epigenetic agent-based immunotherapy  

作　　者：Linkai Jing Zhihong Qian Qiang Gao Rui Sun Zili Zhen Guihuai Wang Xuejun Yang Haitao Li Tiannan Guo Wei Zhang 

机构地区：[1]Department of Neurosurgery,Beijing Tsinghua Changgung Hospital,Tsinghua University,Beijing,People’s Republic of China [2]Department of Basic Medical Sciences,School of Medicine,Tsinghua University,Beijing,People’s Republic of China [3]School of Clinical Medicine,Tsinghua University,Beijing,People’s Republic of China [4]Key Laboratory of Structural Biology of Zhejiang Province,School of Life Sciences,Westlake University,Zhejiang,People’s Republic of China [5]Institute of Basic Medical Sciences,Westlake Institute for Advanced Study,Zhejiang,People’s Republic of China [6]Ministry of Education Key Laboratory of Protein Sciences,Beijing Advanced Innovation Center for Structural Biology,Beijing Frontier Research Center for Biological Structure,Department of Basic Medical Sciences,School of Medicine,Tsinghua University,Beijing,People’s Republic of China [7]Tsinghua-Peking Center for Life Sciences,Tsinghua University,Beijing,People’s Republic of China [8]IDG/McGovern Institute for Brain Research,School of Life Sciences,Tsinghua University,Beijing,People’s Republic of China

出　　处：《Signal Transduction and Targeted Therapy》2023年第2期365-368,共4页信号转导与靶向治疗（英文）

基　　金：This work was supported by Institute of Biomedicine and Tsinghua-Peking Joint Center for Life Sciences and Clinical Medicine Development Fund of Tsinghua University(10001020510).

摘　　要：Dear Editor,Diffuse midline glioma,H3K27-altered(DMG),is a pediatric-type high-grade diffuse glioma that preferentially localizes to the brainstem or pons,thalamus,and spinal cord.Surgical resection is challenging and biopsy is often performed in most cases.To date,no conventional,targeted or immune therapy has been convincingly shown to improve patients’overall survival(OS).

关 键 词：GLIOMA IMMUNOTHERAPY BRAINSTEM 

分 类 号：R730.51[医药卫生—肿瘤]