Glycan targeting nanoparticle for photodynamic immunotherapy of melanoma  

作　　者：Yonghyun Choi Wooic Son Youngpin Han Jayoung Chae Chul-Su Yang Jonghoon Choi 

机构地区：[1]School of Integrative Engineering,Chung-Ang University,Seoul 06974,Republic of Korea [2]Department of Molecular&Life Science,Hanyang University,Ansan 15588,Republic of Korea [3]Center for Bionano Intelligence Education and Research,Hanyang University,Ansan 15588,Republic of Korea

出　　处：《Acta Pharmaceutica Sinica B》2023年第5期1903-1918,共16页药学学报（英文版）

基　　金：a National Research Foundation of Korea(NRF)grant the Korean government(MSIT)(Nos.2020R1A5A1018052,2017M3A7B8061942,2019R1A2C1006018,2021R1A4A5032463 and 2021M3H4A4079629,Republic of Korea)。

摘　　要：Interaction between tumour cells and macrophages enables cancer cells to evade immune detection and clearance by interfering with macrophage phagocytosis.The anti-phagocytic signals regulated by anti-phagocytic proteins are termed"don't eat me"signals;these signals include sialic acidbinding immunoglobulin-type lectin-10(Siglec-10)and the recently revealed CD24 immune checkpoint(ICP).In this study,we demonstrate that targeting a specific glycan on CD24 exhibits the potential to inhibit ICP.Sambucus nigra agglutinin(SNA),a sialic acid-binding lectin,was employed to block CD24 and to enhance phagocytosis in melanoma tumours.In addition,we prepared SNA-conjugated hollow gold-iron oxide nanoparticles for photothermal therapy of tumours.Our findings show that the combination treatment of SNA-conjugated photothermal nanoparticles and near-infrared exposure successfully augments tumour cell phagocytosis both in vitro and in vivo models.

关 键 词：IMMUNOTHERAPY Macrophages PHAGOCYTOSIS LECTIN Melanoma cancer Photothermal nanoparticles Immune checkpoint GLYCAN 

分 类 号：R739.5[医药卫生—肿瘤]