GLYCAN

作品数：39被引量：58H指数：4
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相关领域：医药卫生生物学更多>>
相关作者：曾文锋卜东波王继群孙瑾章晓联更多>>
相关机构：沃特世科技(上海)有限公司中国科学院华中科技大学暨南大学附属第一医院更多>>
相关期刊：《Chemical Research in Chinese Universities》《National Science Review》《Cancer Biology & Medicine》《Acta Biochimica et Biophysica Sinica》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Integration of resol/block-copolymer carbonization and machine learning:A convenient approach for precise monitoring of glycan-associated disorders
《Chinese Chemical Letters》2024年第12期482-486,共5页Yiwen Lin Yijie Chen Chunhui Deng Nianrong Sun 
supported by National Key R&D Program of China(No.2018YFA0507501);the National Natural Science Foundation of China(Nos.22074019,21425518,22004017);Shanghai Sailing Program(No.20YF1405300)。
Ensuring the timely and precise monitoring of severe liver diseases is crucial for guiding effective therapies and significantly extending overall quality of life.However,this remains a worldwide challenge,given the h...
关键词：N-GLYCAN Mesoporous carbon MALDI-TOF MS Machine learning model Liver disease 
Deciphering disease through glycan codes:leveraging lectin microarrays for clinical insights被引量：1
《Acta Biochimica et Biophysica Sinica》2024年第8期1145-1155,共11页Hangzhou Yang Zihan Lin Bo Wu Jun Xu Sheng-Ce Tao Shumin Zhou 
supported by the grant from the Funding of Shanghai Sixth People Hospital(No.ynms202202).
Glycosylation,a crucial posttranslational modification,plays a significant role in numerous physiological and pathological processes.Lectin microarrays,which leverage the high specificity of lectins for sugar binding,...
关键词：lectin microarray clinical sample GLYCOMICS GLYCANS biomarkers 
Dietary eubiotics of microbial muramidase and glycan improve intestinal villi,ileum microbiota composition and production trait of broiler
《Journal of Animal Science and Biotechnology》2024年第4期1723-1736,共14页Sungbo Cho Shanmugam Suresh Kumar Santiago Ramirez Rolando Valientes In Ho Kim 
supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(NRF-RS-2023-00275307)。
Background Optimal gut health is important to maximize growth performance and feed efficiency in broiler chickens.A total of 1,365 one-day-old male Ross 308 broiler chickens were randomly divided into 5 treatments gro...
关键词：BROILER Intestinal morphology Microbial muramidase Precision glycan Probiotics 
Blockade of Rho-associated kinase prevents inhibition of axon regeneration of peripheral nerves induced by anti-ganglioside antibodies被引量：1
《Neural Regeneration Research》2024年第4期895-899,共5页Andrés Berardo Cristian R.Bacaglio Bárbara B.Báez Rubén Sambuelli Kazim A.Sheikh Pablo H.H.Lopez 
supported by Fondo para la Investigación Cientifica y Tecnológica(FONCy T),Argentina,grant#PICT 2015-2473(to PHHL);supported by grants from National Institute of Health/National Institute of Neurological Disorders and Stroke(NIH/NINDS,USA)(NS121621);Department of Defense,USA(Do D-CL1)(PR200530);partially financed with a fellowship for Research in Medicine from Fundación Florencio Fiorini;supported with a PhD fellowship from CONICET。
Anti-ganglioside antibodies are associated with delayed/poor clinical recovery in Guillain-Barrèsyndrome,mostly related to halted axon regeneration.Cross-linking of cell surface gangliosides by anti-ganglioside antib...
关键词：anti-ganglioside antibodies anti-glycan antibodies axon regeneration GANGLIOSIDE Guillain-Barrésyndrome nerve repair ROCK Y-27632 
Chemoselective labeling-based spermatozoa glycan imaging reveals abnormal glycosylation in oligoasthenotspermia
《Chinese Chemical Letters》2024年第4期475-480,共6页Lijia Xu Tong Zhong Wei Zhao Bing Yao Lin Ding Huangxian Ju 
the support from the National Natural Science Foundation of China (Nos.21974067, 22274073, 81971373 and 82001535);the National Key Research and Development Program of China (No.2018YFC1004700);Fundamental Research Funds for the Central Universities (Nos.020514380309,021414380502 and 2022300324);the State Key Laboratory of Analytical Chemistry for Life Science (Nos.5431ZZXM2305 and 5431ZZXM2204)。
Spermatogenesis, maturation, capacitation and fertilization are precisely regulated by glycosylation. However, the relationship between altered glycosylation patterns and the onset and development of reproductive diso...
关键词：SPERMATOZOA GLYCAN Chemoselective labeling Oligoasthenotspermia Fluorescence imaging 
Semisynthesis of homogeneous spike RBD glycoforms from SARS-CoV-2 for profiling the correlations between glycan composition and function被引量：2
《National Science Review》2024年第2期140-149,共10页Farong Ye Cheng Li Feng-Liang Liu Xinliang Liu Peng Xu Rong-Hua Luo Wenping Song Yong-Tang Zheng Tianlei Ying Biao Yu Ping Wang 
supported by the National Science Fund for Distinguished Young Scholars (22225701);National Natural Science Foundation of China (92253302, 22077080 and 31970879);Shanghai Pilot Program for Basic Research-Shanghai Jiao Tong University (21TQ1400210);National Key R&D Program of China (2021YFC2301303 and 2022YFC2303700);Special Projects of the Central Government in Guidance of Local Science and Technology Development (2021Szvup077)
Vaccines have been the primary remedy in the global fight against coronavirus disease 2019(COVID-19).The receptor-binding domain(RBD)of the spike protein,a critical viral immunogen,is affected by the heterogeneity of ...
关键词：peptide ligation GLYCOSYLATION GLYCOPROTEIN 
Immunological Exploration of Helicobacter pylori Serotype O_(2) O-Antigen by Using a Synthetic Glycan Library被引量：3
《Chinese Journal of Chemistry》2024年第3期243-251,共9页Ming Zhao Guangzong Tian Chunjun Qin Xiaopeng Zou Peter H. Seeberger Jing Hu Jian Yin 
financial support from the National Natural Science Foundation of China(22177041,22277042,22077052,22107037,22207042);the China Postdoctoral Science Foundation(2021M691279);the 111 Project(111-2-06);the Max Planck Society International Partner Group Program,and the China Scholarship Council(CSC)for funding.P.H.S.thanks the Max Plank Society forgenerous financial support.
Helicobacter pylori(H.pylori)infection is a threat to human health.The lipopolysaccharide(LPS)O-antigen holds promise for developing vaccines.It is meaningful to explore the immunological activity of oligosaccharides ...
关键词：GLYCOCONJUGATES Helicobacter pylori Immunology Microarrays O-ANTIGEN OLIGOSACCHARIDES 
Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection被引量：2
《Cellular & Molecular Immunology》2023年第10期1101-1113,共13页SaloméS.Pinho Inês Alves Joana Gaifem Gabriel A.Rabinovich 
supported by grants from SSP:co-funded by the European Union(ERC,GlycanSwitch,101071386).Views and opinions expressed are however those of the author(s)only and do not necessarily reflect those of the European Union or the European Research Council Executive Agency.Neither the European Union nor the granting authority can be held responsible for them.The work was also co-funded by EU GlycanTrigger-grant Agreement No:101093997.Views and opinions expressed are however those of the author(s)only and do not necessarily reflect those of the European Union or European Health and Digital Executive Agency.Neither the European Union nor the granting authority can be held responsible for them.SSP also acknowledges funding by“2022 LRA Lupus Innovation Award”and by“European Crohn’s and Colitis Organisation(ECCO)Pioneer Award 2021”.SSP also acknowledges the US Department of Defense,US Army Medical Research Acquisition Activity,FY18 Peer Reviewed Medical Research Program Investigator-Initiated Research Award(award number W81XWH1920053)as well as grant funded by the Portuguese Foundation for Science and Technology–FCT(EXPL/MED-ONC/0496/2021).IA acknowledges FCT for funding(2022.00337.CEECIND).JG acknowledges funding from ESCMID(ESCMID Research Grant 2022),ECCO(ECCO Grant 2023)and FCT(2020.00088.CEECIND).G.A.R acknowledges grants from the Argentinean Agency for Promotion of Science,Technology and Innovation(PICT 2017-0494,PICT-FBB 620 and PICT 2020-01552).The authors are also thankful for generous support from Sales(Argentina),Bunge&Born(Argentina),Baron(Argentina),Williams(Argentina)and Richard Lounsbery(USA)Foundations,as well as donations from Ferioli-Ostry and Caraballo families to GAR.
The immune system is coordinated by an intricate network of stimulatory and inhibitory circuits that regulate host responses against endogenous and exogenous insults.Disruption of these safeguard and homeostatic mecha...
关键词：Immune response Inflammation INFECTION GLYCANS GLYCOSYLATION Glycan-binding proteins 
A Genome‑Wide Association Study for Susceptibility to Axial Length in Highly Myopic Eyes被引量：1
《Phenomics》2023年第3期255-267,共13页Qiang Lu Yu Du Ye Zhang Yuxi Chen Hao Li Wenwen He Yating Tang Zhennan Zhao Yinglei Zhang Jihong Wu Xiangjia Zhu Yi Lu 
Funding was provided by the National Natural Science Foundation of China,82122017:Xiangjia Zhu,81970780:Yi Lu,81870642:Xiangjia Zhu,81670835:Yi Lu;Science and Technology Innovation Plan of Shanghai Science and Technology Commission,19441900700:Xiangjia Zhu,21S31904900:Xiangjia Zhu;Shanghai Hospital Development Center,SHDC12019X08:Xiangjia Zhu;Shanghai Shenkang Hospital Development Center,SHDC2020CR4078:Xiangjia Zhu;Double-E Plan of Eye&ENT Hospital,SYA202006:Xiangjia Zhu;Shanghai Municipal Key Clinical Specialty Program,shslczdzk01901:Xiangjia Zhu.
High myopia has long been highly prevalent worldwide with a largely yet unexplained genetic contribution.To identify novel susceptibility genes for axial length(AL)in highly myopic eyes,a genome-wide association study...
关键词：Axial length High myopia Whole-genome sequencing ADAM Metallopeptidase With Thrombospondin Type 1 Motif 16·Phosphatidylinositol Glycan Anchor Biosynthesis Class Z 
Glycan targeting nanoparticle for photodynamic immunotherapy of melanoma被引量：1
《Acta Pharmaceutica Sinica B》2023年第5期1903-1918,共16页Yonghyun Choi Wooic Son Youngpin Han Jayoung Chae Chul-Su Yang Jonghoon Choi 
a National Research Foundation of Korea(NRF)grant the Korean government(MSIT)(Nos.2020R1A5A1018052,2017M3A7B8061942,2019R1A2C1006018,2021R1A4A5032463 and 2021M3H4A4079629,Republic of Korea)。
Interaction between tumour cells and macrophages enables cancer cells to evade immune detection and clearance by interfering with macrophage phagocytosis.The anti-phagocytic signals regulated by anti-phagocytic protei...
关键词：IMMUNOTHERAPY Macrophages PHAGOCYTOSIS LECTIN Melanoma cancer Photothermal nanoparticles Immune checkpoint GLYCAN 
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