Role of glioma immune biomarker ORMDL2 in the diagnosis and prognosis of glioma  

作　　者：YAN Dong-ming LIANG Jian-tang LIU Xiao-qian LI Meng-yongwei DING Shun MENG Qing-wen ZHANG Si-yuan TANG Cai-ying LIU Qi-bing YANG Kun 

机构地区：[1]Department of Neurosurgery,The First Affiliated Hospital of Hainan Medical University,Haikou 570102,China [2]Department of Neurology,The First Affiliated Hospital of Hainan Medical University,Haikou 570102,China [3]Trauma Center of the First Affiliated Hospital of Hainan Medical University,Haikou 570102,China [4]Department of Reproductive Medicine,The First Affiliated Hospital of Hainan Medical University,Haikou 570102,China [5]Department of Otorhinolaryngology Head and Neck Surgery,The First Affiliated Hospital of Hainan Medical University,Haikou 570102,China [6]Department of Cardiovascular Medicine,The First Affiliated Hospital of Hainan Medical University,Haikou 570102,China [7]Pharmacy Department of the First Affiliated Hospital of Hainan Medical University,Haikou 570102,China

出　　处：《Journal of Hainan Medical University》2023年第6期28-36,共9页海南医学院学报（英文版）

基　　金：Finance Science and Technology Project of Hainan Province(ZDYF2022SHFZ088),Hainan Medical University Postgraduate Innovative Research Project Category B(HYYS2021B16)。

摘　　要：Obiective:To investigate the prognostic value of ORMDL2 in human glioma and its relationship with immune invasion.Methods:The clinical survival data from TCGA-LGG&GBM,CGGA and GEO were used to evaluate the clinical prognostic value of ORMDL2.The cut off value of ORMDL2 was detected with pROC package to draw ROC curve to prove its value in differential diagnosis of glioma.The first 300 genes with the most significant positive correlation with ORMDL2 were selected to establish PPI network through STRING database and conduct GO and pathway analysis.The relationship between the expression of ORMDL2 mRNA and immune cell infiltration was investigated by using ssGSEA and TIMER2.0 databases.Results:The expression of ORMDL2 mRNA in glioma was significantly higher than that in adjacent normal tissues,and the difference was most significant in high-grade glioma.The expression of ORMDL2 was increased in human glioma,which was related to the clinicopathological characteristics and poor prognosis of glioma patients.In addition,the increased expression of ORMDL2 was associated with a series of immune infiltrating cells,including macrophages.Conclusion:ORMDL2 plays an important role in glioma immune cell infiltration and is a biomarker of prognosis of glioma patients.

关 键 词：GLIOMA ORMDL2 SPHINGOLIPID Immune infiltration BIOMARKER 

分 类 号：R739.41[医药卫生—肿瘤]