Effects of Zhenggan Huayu decoction(正肝化瘀方)combined with entecavir on gut microbiota in patients with chronic hepatitis B fibrosis  

作　　者：CHEN Wenlin LIANG Fang ZHANG Yuncheng LV Jinzhen YANG Daguo 

机构地区：[1]Department of Liver Diseases,Shenzhen Hospital,Beijing University of Chinese Medicine,Shenzhen 518172,China [2]Department of Liver Diseases,Shenzhen Third People's Hospital,Guangdong 518112,China

出　　处：《Journal of Traditional Chinese Medicine》2023年第3期559-567,共9页中医杂志（英文版）

基　　金：Supported by Shenzhen Science and Technology Plan Project:Study on the Mechanism of Zhenggan Huayu Decoction Regulating Intestinal Flora in Liver Fibrosis based on LPS-TRL4 Signal Pathway(No.JCYJ20180302150216419)。

摘　　要：OBJECTIVE:To evaluate the effects of Zhenggan Huayu decoction(正肝化瘀方,ZGHY) combined with entecavir(ETV) on the gut microbiota in patients with chronic hepatitis B(CHB) fibrosis.METHODS:A total of 59 CHB-related fibrosis patients were enrolled and treated with ZGHY combined with ETV(ZGHY + ETV) and ETV alone.Fecal samples were collected from patients at weeks 0,12,and 24 after treatment and gut microbiota were analyzed by 16S r RNA gene sequencing.RESULTS:Compared to the ETV group,microbiota diversity in the ZGHY + ETV group was increased after 24 weeks.Some potentially pathogenic bacteria,including Fusobacteriaceae spp.,Acidaminococcus spp.,and Erysipelotrichaceae spp.were reduced in the ZGHY + ETV group,while Eubacteriaceae spp.,Lactococcus spp.,and several other beneficial bacteria were increased.CONCLUSION:Decreases in pathogenic bacteria and increases in probiotics were not always observed in the Traditional Chinese Medicine(TCM) group(e.g.,Rothia was abundant).As an adjuvant TCM formulation for ETV,ZGHY had a positive role in the treatment of CHB patients.

关 键 词：hepatitis B CHRONIC FIBROSIS RNA RIBOSOMAL 16S Zhenggan Huayu decoction ENTECAVIR gut microbiota 

分 类 号：R512.62[医药卫生—内科学] R575.2[医药卫生—临床医学]