Biomaterials-based anti-inflammatory treatment strategies for Alzheimer's disease  

作　　者：Jianjian Chu Weicong Zhang Yan Liu Baofeng Gong Wenbo Ji Tong Yin Chao Gao Danqi Liangwen Mengqi Hao Cuimin Chen Jianhua Zhuang Jie Gao You Yin 

机构地区：[1]Department of Neurology,Second Affiliated Hospital(Shanghai Changzheng Hospital)of Naval Medical University,Shanghai,China [2]School of Pharmacy,University College London,London,UK [3]Department of Clinical Pharmacy,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,Clinical Pharmacy Innovation Institute,Shanghai Jiao Tong University School of Medicine,Shanghai,China [4]School of Health Science and Engineering,University of Shanghai for Science and Technology,Shanghai,China [5]Changhai Clinical Research Unit,Shanghai Changhai Hospital,Naval Medical University,Shanghai,China

出　　处：《Neural Regeneration Research》2024年第1期100-115,共16页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,Nos.82072051 and 81771964(both to JG);the Natural Science Foundation of Shanghai Municipal Science and Technology Commission,No.22ZR147750(to YY);Science and Technology Support Projects in Biomedicine Field of Shanghai Science and Technology Commission,No.19441907500(to YY);Innovative Clinical Research Project of Changzheng Hospital,No.2020 YLCYJ-Y02(to YY);Characteristic Medical Service Project for the Army of Changzheng Hospital,No.2020 CZWJFW12(to YY)。

摘　　要：The current therapeutic drugs for Alzheimer's disease only improve symptoms,they do not delay disease progression.Therefo re,there is an urgent need for new effective drugs.The underlying pathogenic factors of Alzheimer's disease are not clear,but neuroinflammation can link various hypotheses of Alzheimer's disease;hence,targeting neuroinflammation may be a new hope for Alzheimer's disease treatment.Inhibiting inflammation can restore neuronal function,promote neuro regeneration,reduce the pathological burden of Alzheimer's disease,and improve or even reverse symptoms of Alzheimer's disease.This review focuses on the relationship between inflammation and various pathological hypotheses of Alzheimer's disease;reports the mechanisms and characteristics of small-molecule drugs(e.g.,nonsteroidal anti-inflammatory drugs,neurosteroids,and plant extracts);macromolecule drugs(e.g.,peptides,proteins,and gene therapeutics);and nanocarriers(e.g.,lipid-based nanoparticles,polymeric nanoparticles,nanoemulsions,and inorganic nanoparticles)in the treatment of Alzheimer's disease.The review also makes recommendations for the prospective development of anti-inflammatory strategies based on nanocarriers for the treatment of Alzheimer's disease.

关 键 词：Alzheimer's disease ANTI-INFLAMMATION blood-brain barrier drug delivery MICROGLIA NANOPARTICLES NEUROINFLAMMATION plant extracts 

分 类 号：R749.16[医药卫生—神经病学与精神病学]