Contribution of glial cells to the neuroprotective effects triggered by repetitive magnetic stimulation:a systematic review  

作　　者：Susana A.Ferreira Nuno Pinto Inês Serrenho Maria Vaz Pato Graça Baltazar 

机构地区：[1]Centro de Investigação em Ciências da Saúde(CICS-UBI),Universidade da Beira Interior,Covilhã,Portugal [2]Faculdade de Ciências da Saúde,Universidade da Beira Interior,Covilhã,Portugal [3]GRUBI-Systematic Reviews Group,University of Beira Interior,Covilhã,Portugal

出　　处：《Neural Regeneration Research》2024年第1期116-123,共8页中国神经再生研究（英文版）

基　　金：the scope of the CICS-UBI projects UIDP/Multi/00709/2019,UIDB/Multi/00709/2019,UIDP/00709/2020,UIDB/00709/2020,financed by national funds through the Portuguese Foundation for Science and Technology/MCTES;by funds to the PPBI-Portuguese Platform of Bio Imaging through the Project POCI-01-0145-FEDER-022122(to GB,MVP,NP);supported by a grant from the Portuguese Foundation for Science and Technology/MCTES(2021.07854.BD)(to IS)。

摘　　要：Repetitive transcranial magnetic stimulation has been increasingly studied in different neurological diseases,and although most studies focus on its effects on neuronal cells,the contribution of nonneuronal cells to the improvement trigge red by repetitive transcranial magnetic stimulation in these diseases has been increasingly suggested.To systematically review the effects of repetitive magnetic stimulation on non-neuronal cells two online databases.Web of Science and PubMed were searched fo r the effects of high-frequency-repetitive transcranial magnetic stimulation,low-frequencyrepetitive transcranial magnetic stimulation,intermittent theta-bu rst stimulation,continuous thetaburst stimulation,or repetitive magnetic stimulation on non-neuronal cells in models of disease and in unlesioned animals or cells.A total of 52 studies were included.The protocol more frequently used was high-frequency-repetitive magnetic stimulation,and in models of disease,most studies report that high-frequency-repetitive magnetic stimulation led to a decrease in astrocyte and mic roglial reactivity,a decrease in the release of pro-inflammatory cyto kines,and an increase of oligodendrocyte proliferation.The trend towards decreased microglial and astrocyte reactivity as well as increased oligodendrocyte proliferation occurred with intermittent theta-burst stimulation and continuous theta-burst stimulation.Few papers analyzed the low-frequency-repetitive transcranial magnetic stimulation protocol,and the parameters evaluated were restricted to the study of astrocyte reactivity and release of pro-inflammatory cytokines,repo rting the absence of effects on these paramete rs.In what concerns the use of magnetic stimulation in unlesioned animals or cells,most articles on all four types of stimulation reported a lack of effects.It is also important to point out that the studies were developed mostly in male rodents,not evaluating possible diffe rential effects of repetitive transcranial magnetic stimulation between sexes.This systematic revi

关 键 词：ASTROCYTE GLIA high-frequency repetitive magnetic stimulation inflammation low-frequency repetitive magnetic stimulation MICROGLIA neurologic disorders OLIGODENDROCYTE repetitive magnetic stimulation theta-burst stimulation 

分 类 号：R741.05[医药卫生—神经病学与精神病学]