纳米结构脂质载体制备及在功能食品中的应用研究进展  

Research Progress in Preparation of Nanostructured Lipid Carriers and Its Application in Functional Foods

作　　者：史凡[1] 杨红[1] SHI Fan;YANG Hong(Yanjing Medical College,Capital Medical University,Beijing 101300,China)

机构地区：[1]首都医科大学燕京医学院,北京101300

出　　处：《食品工业科技》2023年第15期1-6,共6页Science and Technology of Food Industry

摘　　要：纳米结构脂质载体是食品工业中的新剂型,作为功能食品的递送系统,具有较高的载药量和包封率,可有效增加脂溶性生物活性物质的生物利用度和稳定性,提升食品营养价值和安全性,并能控制包封材料的释放,具有广阔的应用前景。本文综述了纳米结构脂质载体的结构特征分类(缺陷型、无定型和复合型)与常用制备方法,即热或冷高压均质法、溶剂扩散法、溶剂蒸发法、溶剂注入/溶剂置换法、微乳法、乳化超声法、薄膜接触器法、相转化技术和超临界流体技术的工艺流程及优缺点;总结了纳米结构脂质载体对功能食品领域中必需脂肪酸、类胡萝卜素、植物甾醇、脂溶性维生素、多酚类化合物等生物活性物质的保护与传递;并对纳米结构脂质载体递送体系在食品领域存在的局限性及未来研究趋势进行了总结和探讨,以期为后续研究提供参考。Nanostructured lipid carriers is a new dosage form in food industry.As a delivery system for functional foods,it has a high drug loading and encapsulation rate,which can effectively increase the bioavailability and stability of fat-soluble bioactive substances,improve the nutritional value and safety of food,and control the release of encapsulating materials,so it has a broad application prospect.In this paper,the classification of structural characteristics(imperfect type,amorphous type and multiple type)and several common preparation methods of nanostructured lipid carriers are reviewed,including the process flow as well as the advantages and drawbacks of hot high-pressure homogenization,cold high-pressure homogenization,solvent emulsification diffusion method,solvent emulsification evaporation method,solvent injection/solvent displacement method,microemulsion technique,emulsification ultrasonic method,membrane contractor,phase inversion techniques and super critical fluid method.The protection and delivery of nanostructured lipid carriers for essential fatty acids,carotenoids,phytosterols,fat-soluble vitamins,polyphenols and other bioactive substances in functional food field are summarized.The limitations and future research trends of nanostructured lipid carriers delivery system in food industry are summarized and discussed,which would provide a theoretical basis for subsequent research.

关 键 词：纳米结构脂质载体 功能食品 生物活性物质 递送系统 制备工艺 应用 

分 类 号：TS201.2[轻工技术与工程—食品科学]