Novel insights into D-Pinitol based therapies:a link between tau hyperphosphorylation and insulin resistance  

作　　者：Dina Medina-Vera Antonio Jesús López-Gambero Juan Antonio Navarro Carlos Sanjuan Elena Baixeras Juan Decara Fernando Rodríguez de Fonseca 

机构地区：[1]Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND,UGC Salud Mental,Málaga,Spain [2]Facultad de Ciencias,Universidad de Málaga,Málaga,Spain [3]CIBER Enfermedades Cardiovasculares(CIBERCV),Hospital Universitario Virgen de la Victoria,UGC del Corazón,Málaga,Spain [4]University of Bordeaux,INSERM,Neurocentre Magendie,Bordeaux,France [5]Euronutra S.L.Calle Johannes Kepler,Málaga,Spain [6]Departamento de Bioquímica y Biología Molecular,Facultad de Medicina,Universidad de Málaga,Málaga,Spain

出　　处：《Neural Regeneration Research》2024年第2期289-295,共7页中国神经再生研究（英文版）

基　　金：supported by the European Regional Development Funds-European Union(ERDF-EU),FATZHEIMER project(EU-LAC HEALTH 2020,16/T010131 to FRdF),“Una manera de hacer Europa”;Ministerio de Economía,Industria y Competitividad,Gobierno de Espa?a,Programa Estatal de Investigación,Desarrollo e Innovación Orientada a los Retos de la Sociedad(RTC2019-007329-1 to FRdF);Consejería de Economía,Conocimiento y Universidad,Junta de Andalucía,Plan Andaluz de Investigación,Desarrollo e Innovación(P18TP-5194 to FRdF);Instituto de Salud CarlosⅢ(DTS22/00021 to FRdF);DMV(FI20/00227)holds a“PFIS’’predoctoral contract from the National System of Health,EU-ERDF-Instituto de Salud CarlosⅢ。

摘　　要：Alzheimer’s disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer’s disease.The pathogenesis of Alzheimer’s disease is mainly mediated by the phosphorylation and aggregation of tau protein.Among the multiple causes of tau hyperphosphorylation,brain insulin resistance has generated much attention,and inositols as insulin sensitizers,are currently considered candidates for drug development.The present narrative review revises the interactions between these three elements:Alzheimer’s disease-tau-inositols,which can eventually identify targets for new disease modifiers capable of bringing hope to the millions of people affected by this devastating disease.

关 键 词：Alzheimer’s disease cyclin-dependent kinase 5 diabetes D-PINITOL inositols insulin resistance KINASES PHOSPHORYLATION PI3K/Akt tau 

分 类 号：R749.16[医药卫生—神经病学与精神病学]