Role of transforming growth factor-βin peripheral nerve regeneration  

作　　者：Zihan Ding Maorong Jiang Jiaxi Qian Dandan Gu Huiyuan Bai Min Cai Dengbing Yao 

机构地区：[1]School of Life Sciences,Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education,Co-innovation Center of Neuroregeneration,Nantong University,Nantong,Jiangsu Province,China [2]Medical School of Nantong University,Nantong,Jiangsu Province,China

出　　处：《Neural Regeneration Research》2024年第2期380-386,共7页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,Nos.31971277 and 31950410551(both to DY)。

摘　　要：Injuries caused by trauma and neurodegenerative diseases can damage the peripheral nervous system and cause functional deficits.Unlike in the central nervous system,damaged axons in peripheral nerves can be induced to regenerate in response to intrinsic cues after reprogramming or in a growth-promoting microenvironment created by Schwann cells.However,axon regeneration and repair do not automatically result in the restoration of function,which is the ultimate therapeutic goal but also a major clinical challenge.Transforming growth factor(TGF)is a multifunctional cytokine that regulates various biological processes including tissue repair,embryo development,and cell growth and differentiation.There is accumulating evidence that TGF-βfamily proteins participate in peripheral nerve repair through various factors and signaling pathways by regulating the growth and transformation of Schwann cells;recruiting specific immune cells;controlling the permeability of the blood-nerve barrier,thereby stimulating axon growth;and inhibiting remyelination of regenerated axons.TGF-βhas been applied to the treatment of peripheral nerve injury in animal models.In this context,we review the functions of TGF-βin peripheral nerve regeneration and potential clinical applications.

关 键 词：MYELINATION nerve repair and regeneration NEURITE NEUROINFLAMMATION peripheral nerve injury Schwann cell transforming growth factor-β Wallerian degeneration 

分 类 号：R741[医药卫生—神经病学与精神病学]