Endostatin specifically targets both tumor blood vessels and lymphatic vessels  

作　　者：Wei Zhuo Yang Chen Xiaomin Song Yongzhang Luo 

机构地区：[1]National Engineering Laboratory for Anti-tumor Protein Therapeutics,Beijing 100084,China [2]Beijing Key Laboratory for Protein Therapeutics,Beijing 100084,China [3]Cancer Biology Laboratory,School of Life Sciences,Tsinghua University,Beijing 100084,China

出　　处：《Frontiers of Medicine》2011年第4期336-340,共5页医学前沿（英文版）

基　　金：This work was supported in part by the General Programs of the National Natural Science Foundation of China(Grant No.30771083);the National High Technology Research and Development Program of China(No.2007AA02Z155 and No.2008AA02Z136);the National Science and Technology Major Project(No.2009ZX09103-703 and No.2009ZX09306-002)。

摘　　要：Endostatin,a 20 kDa C-terminal fragment of collagen XVIII,was first identified as a potent angiogenic inhibitor.The anti-angiogenic function of endostatin has been well documented during the past decade.Recently,several studies demonstrated that endostatin also inhibits tumor lymphangiogenesis and lymphatic metastasis.However,the exact mechanism that endostatin executes its anti-angiogenic and anti-lymphangiogenic functions remains elusive.In the current mini-review,we briefly summarize recent novel findings,including the functions of endostatin targeting not only angiogenesis but also lymphangiogenesis,and the underlying mechanism by which endostatin internalization regulates its biological functions.

关 键 词：ENDOSTATIN ANGIOGENESIS LYMPHANGIOGENESIS NYSTATIN INTERNALIZATION TUMOR 

分 类 号：R73[医药卫生—肿瘤]