NMDA receptor signaling:death or survival?  

作　　者：Tong LUO Wei-Hua WU Bo-Shiun CHEN 

机构地区：[1]Institute of Molecular Medicine and Genetics,Department of Neurology,Georgia Health Sciences University,Augusta,GA 30912,USA

出　　处：《Frontiers in Biology》2011年第6期468-476,共9页生物学前沿（英文版）

基　　金：supported by a NINDS Career Transition Award(to B.-S.C.).

摘　　要：Glutamate-induced neuronal damage is mainly caused by overactivation of N-methyl-D-aspartate(NMDA)receptors.Conversely,normal physiological brain function and neuronal survival require adequate activation of NMDA receptors.Studies have revealed that NMDA receptor-induced neuronal death or survival is mediated through distinct subset of NMDA receptors triggering different intracellular signaling pathways.Here we discuss recent advances in the characterization of NMDA receptors in neuronal protection,emphasizing subunit-specific role,which contributes to temporal-spatial distribution,subcellular localization and diverse channel properties of NMDA receptors.

关 键 词：NMDA receptors GLUTAMATE EXCITOTOXICITY ISCHEMIA NEUROPROTECTION 

分 类 号：R74[医药卫生—神经病学与精神病学]