大蒜多糖对健康小鼠肠道菌群及免疫功能的影响  

Effects of Garlic Polysaccharide on Intestinal Flora and Immune Function of Healthy Mice

作　　者：赵人杰 白芯嫣 项璐 卢晓明[1] 乔旭光[1] Zhao Renjie;Bai Xinyan;Xiang Lu;Lu Xiaoming;Qiao Xuguang(College of Food Science and Engineering,Shandong Agricultural University,Key Laboratory of Food Nutrition and Healthy in Shandong Province,Taian 271018,Shandong)

机构地区：[1]山东农业大学食品科学与工程学院,山东省高等学校食品营养与健康重点实验室,山东泰安271018

出　　处：《中国食品学报》2023年第8期132-141,共10页Journal of Chinese Institute Of Food Science and Technology

基　　金：国家自然科学基金项目(31801559);山东省重点研发计划重大科技创新项目(2019JZZY020607);山东省泰山领军人才专项基金项目(tscy20200121)。

摘　　要：采用体外模拟消化评价大蒜多糖的消化特性,研究其对健康小鼠免疫机能及肠道菌群的影响。结果显示,大蒜多糖表现出较好的抗消化特性,约93%的大蒜多糖经过口腔及胃肠道消化后不被水解而被肠道内微生物利用。动物实验表明,大蒜多糖可以促进小鼠脾脏的生长发育,同时显著提高血清IgA(34.56%)、IgM(39.56%)、IgG(106.22%)以及粪便SIgA(61.54%)的含量。此外,大蒜多糖还可以改善小鼠肠道环境,包括促进有益菌(例如双歧杆菌及乳酸杆菌)的增殖,抑制有害菌的生长并提高乙酸及丙酸的水平。这一结果表明大蒜多糖可作为益生元,增强机体的免疫功能。The digestive properties of garlic polysaccharides were evaluated by simulating digestion in vitro and their effects on the immune function and intestinal flora of healthy mice were investigated.The results showed that garlic polysaccharides exhibited good anti-digestive properties,and approximately 93%of garlic polysaccharides could not hydrolyzed after oral and gastrointestinal digestion and were utilized by microorganisms.The results of animal experiments showed that garlic polysaccharides could promote the growth and development of mouse spleen,and significantly promote the levels of IgA(34.56%),IgM(39.56%)and IgG(106.22%)in serum as well as SIgA(61.54%)in feces.It also improved the intestinal environment of mice,including promoting the proliferation of beneficial bacteria(such as Bifidobacterium and Lactobacillus),inhibiting the growth of harmful bacteria,and increasing the levels of acetic acid and propionic acid.This result demonstrated that garlic polysaccharides could act as prebiotics and enhance the immune function of the body.

关 键 词：大蒜多糖 体外模拟消化 免疫活性 益生活性 

分 类 号：TS201.4[轻工技术与工程—食品科学]