Circulating tumor cells: Biological features and survival mechanisms  

作　　者：XIAOFENG LI JINYANG ZHENG JINFENG ZHU XIN HUANG HUANHUAN ZHU BINGDI CHEN 

机构地区：[1]Department of Oncology,Affiliated Quanzhou First Hospital of Fujian Medical University,Quanzhou,China [2]Department of Pathology,Affiliated Quanzhou First Hospital of Fujian Medical University,Quanzhou,China [3]Department of Medical Oncology,Affiliated Quanzhou First Hospital of Fujian Medical University,Quanzhou,China [4]Department of Dermatology,School of Medicine,Tongji Hospital,Tongji University,Shanghai,China [5]Department of Central Laboratory,Shanghai Tenth People’s Hospital,Shanghai,China [6]Shanghai East Hospital,The Institute for Biomedical Engineering&Nano Science,Tongji University School of Medicine,Shanghai,China

出　　处：《BIOCELL》2023年第8期1771-1781,共11页生物细胞（英文）

基　　金：supported by the Science Foundation of Fujian Province of China(2019J01596).

摘　　要：Circulating tumor cells(CTCs)are neoplastic cells that are detached from primary tumors and enter circulation.Enumeration and characterization of CTCs are of significance in cancer diagnosis,prognosis,and treatment monitoring.CTC survival in the bloodstream is a limiting step for the development of metastases in distant organs.Recent technological advances,especially in single-cell molecular analyses have uncovered heterogeneous CTC survival mechanisms.Undergoing epithelial-to-mesenchymal transition(EMT),increasing stem cell-like properties,and forming cell clusters enable CTCs to adapt to the harsh microenvironment of the circulation.Expressing and releasing several immunosuppressive molecules help CTCs escape from anti-cancer immune mechanisms.This review article summarizes the biological characteristics of CTCs and focuses on the recent understanding of the mechanisms by which CTCs survive in circulation.Additionally,the clinical and therapeutic implications of CTCs are discussed.

关 键 词：ANOIKIS Circulating tumor cells HETEROGENEITY Immune evasion PLASTICITY 

分 类 号：R730.4[医药卫生—肿瘤]