Peripheral ApoE4 Leads to Cerebrovascular Dysfunction and Aβ Deposition in Alzheimer's Disease  

作　　者：Rui Sun Chunming Xie 

机构地区：[1]Department of Neurology,School of Medicine,Affiliated Zhongda Hospital,Southeast University,Nanjing 210009,China [2]Institute of Neuropsychiatry,Affiliated Zhongda Hospital,Southeast University,Nanjing 210009,China [3]The Key Laboratory of Developmental Genes and Human Disease,Southeast University,Nanjing 210009,China

出　　处：《Neuroscience Bulletin》2023年第8期1330-1332,共3页神经科学通报（英文版）

基　　金：supported by the Science and Technology Innovation 2030 Major Projects(2022ZD0211600);the National Natural Science Foundation of China(82271574,82071204,81871069);the Key Projects of Commission of Health,Jiangsu Province(ZDB2020008).

摘　　要：Alzheimer's disease(AD)is a neurodegenerative disease characterized by progressive cognitive dysfunction and behavioral impairment that occurs in old age and pre-old age[1].Apolipoprotein4(ApoE4)is the most important genetic risk factor for late-onset AD[2].Peripheral apoE4 is separated from that in the CNS by the blood-brain barrier(BBB)and is abundantly produced by the liver and macrophages and released into the blood to modulate lipid-related events.

关 键 词：APOE4 ALZHEIMER IMPAIRMENT 

分 类 号：R749.16[医药卫生—神经病学与精神病学]