云南高校图书馆联盟文献共享服务平台- APOE4

APOE4: 作品数：63被引量：102H指数：6; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：李新毅陈晓春张静吕立夏琦祖和更多>>; 相关机构：福建医科大学山西医科大学华中科技大学同济大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金广东省自然科学基金中央高校基本科研业务费专项资金太原市科学技术局科技兴市专项基金更多>>

Rapamycin as a preventive intervention for Alzheimer’s disease in APOE4 carriers:Targeting brain metabolic and vascular restoration: 《Neural Regeneration Research》2026年第2期685-686,共2页Ai-Ling Lin Chetan Aware; supported by National Institute on Aging(NIH-NIA)R01AG054459(to ALL).; Alzheimer’s disease(AD)is the most common form of dementia,affecting over 50 million people worldwide.This figure is projected to nearly double every 20 years,reaching 82 million by 2030 and 152 million by 2050(Alzhe...; 关键词：lipid transporterexists Dementia alzheimer s disease ad RAPAMYCIN Brain metabolic Vascular restoration Amyloid beta plaques APOE

脑深部电刺激联合甘露特钠治疗阿尔茨海默病的疗效及对血清趋化因子CX3CL1及ApoE4水平的影响: 《新疆医科大学学报》2025年第4期482-486,493,共6页罗倩杨伟; 四川省科学技术厅科研基金项目(Q21041)。; 目的探讨脑深部电刺激联合甘露特钠治疗阿尔茨海默病的疗效及对血清趋化因子CX3CL1及ApoE4水平的影响。方法选取2023年8月-2024年8月绵阳市中心医院收治的阿尔茨海默病96例患者为研究对象,采用随机数字表法将其分成研究组(脑深部电刺激...; 关键词：脑深部电刺激甘露特钠阿尔茨海默病趋化因子(C-X3-C基序)配体1 载脂蛋白E4

温肾方调控外泌体ApoE4介导的胆固醇稳态改善甲减认知障碍的机制研究: 《时珍国医国药》2025年第3期440-447,共8页曾明星向楠陈继东邹小娟吴永贵卞庆来吴祖茜张海洋; 湖北省自然科学基金联合基金项目(2023AFD147);湖北省卫计委湖北中医名师工作室建设项目[鄂卫生计生办通(2018)15号];全国中医学术流派传承工作室第二轮建设项目(国中医药人教函[2019]62号)。; 目的基于外泌体ApoE4介导的胆固醇稳态研究温肾方对甲减认知障碍的作用。方法PTU溶解于饮用水中建立甲减模型,60只小鼠随机分为6组,每组10只,干预12周后,OFT、MWM进行行为学检测;生化法检测皮质和海马TC水平,Elisa法检测血清TT_(3)、TT_...; 关键词：甲状腺功能减退症认知障碍外泌体胆固醇稳态温肾方

Microglial APOE4 promotes neuron degeneration in Alzheimer’s disease through inhibition of lipid droplet autophagy: 《Acta Pharmaceutica Sinica B》2025年第1期657-660,共4页Meng Mao Xiwen Ma Xiaochuan Wang Jianping Ye; supported by a project(32271220)from the National Natural Science Foundation of China to Jianping Ye.; The presence of glial lipid droplet(LD)and the apolipoprotein E4(APOE4)genotype have been documented as two major risk factors for the development of Alzheimer’s disease(AD)1,2.However,the intricate molecular interpl...; 关键词：APOE4 Lipid droplets ACSL1 Alzheimer’s disease(AD) MICROGLIA

Understanding genetics, sex and signaling: Implications of sex-dependent APOE4-neutrophil-microglia interactions for Alzheimer’s and tauopathies: 《Signal Transduction and Targeted Therapy》2024年第10期4167-4169,共3页Natja Haag Juliane Bremer Hans Zempel; A recent study published in Nature Medicine uncovers a novel sex-dependent mechanism involving the apolipoprotein E ε4 (APOE4) and in particular neutrophils and their signaling to microglia, which then would mediate ...; 关键词：Alzheimer tau Medicine

脑小血管病中APOE4携带与认知及步态的关系研究: 《中国老年保健医学》2024年第3期26-31,共6页何香花胡才友江东东黄金山梁梅张为; 广西医药卫生适宜技术开发与推广应用项目(编号:S2018012);广西自然科学基金项目(编号:2020GXNSFAA297189)。; 目的研究脑小血管病中APOE4携带与认知及步态的相关性。方法本研究共纳入119例脑小血管病患者,对这些患者进行APOE4基因分型、认知评估、单任务和双任务步态分析,并对上述结果进行统计学分析明确APOE4、认知和步态的关系。结果脑小血管...; 关键词：脑小血管病认知障碍步态单任务双任务

Apolipoprotein E4 interferes with lipid metabolism to exacerbate depression-like behaviors in 5xFAD mice: 《Animal Models and Experimental Medicine》2024年第3期347-361,共15页Yanju Gong Mingfeng Li Min Liu Xinghan Wu Yanhong Li Chuan Qin Ling Zhang; CAMS initiative for Innovative Medicine of China,Grant/Award Number:2021-I2M-1-034。; Background:Apolipoprotein E4(ApoE4)allele is the strongest genetic risk factor for late-onset Alzheimer's disease,and it can aggravate depressive symptoms in non-AD patients.However,the impact of ApoE4 on AD-associate...; 关键词：5xFAD mice Alzheimer's disease ApoE4 allele depression like

TRPV1 alleviates APOE4-dependent microglial antigen presentation and T cell infiltration in Alzheimer’s disease: 《Translational Neurodegeneration》2024年第1期300-323,共24页Jia Lu Kexin Wu Xudong Sha Jiayuan Lin Hongzhuan Chen Zhihua Yu; supported by grants from the National Natural Science Foundation of China(82173791);Science and Technology Commission of Shanghai Municipality(23ZR1436600).; Background Persistent innate and adaptive immune responses in the brain contribute to the progression of Alzhei-mer’s disease(AD).APOE4,the most important genetic risk factor for sporadic AD,encodes apolipoprotein E4...; 关键词：APOE4 CHOLESTEROL TRPV1 MICROGLIA Tau

Linking APOE4/4 genotype to microglial lipid droplets and neurotoxicity in Alzheimer’s disease: 《Translational Neurodegeneration》2024年第1期547-550,共4页Hao Huang Rong Xiang Riqiang Yan; supported by the National Natural Science Foundation of China(82300787,82170598);the Hunan Provincial Key Field R&D Plan Project(2022SK2034);the Natural Science Foundation of Hunan Province(2022JJ30058);the Youth Science Foundation of Xiangya Hospital(2021Q11).; Alzheimer’s disease(AD)is characterized by progressive cognitive decline and is a neurodegenerative disorder that primarily affects the elderly population worldwide.The main neuropathological features of AD include t...; 关键词：Alzheimer AMYLOID SPITE

Peripheral ApoE4 Leads to Cerebrovascular Dysfunction and Aβ Deposition in Alzheimer's Disease: 《Neuroscience Bulletin》2023年第8期1330-1332,共3页Rui Sun Chunming Xie; supported by the Science and Technology Innovation 2030 Major Projects(2022ZD0211600);the National Natural Science Foundation of China(82271574,82071204,81871069);the Key Projects of Commission of Health,Jiangsu Province(ZDB2020008).; Alzheimer's disease(AD)is a neurodegenerative disease characterized by progressive cognitive dysfunction and behavioral impairment that occurs in old age and pre-old age[1].Apolipoprotein4(ApoE4)is the most important ...; 关键词：APOE4 ALZHEIMER IMPAIRMENT

APOE4