云南高校图书馆联盟文献共享服务平台- APOE4

APOE4: 作品数：60被引量：102H指数：6; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：李新毅陈晓春张静吕立夏琦祖和更多>>; 相关机构：福建医科大学山西医科大学华中科技大学同济大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金广东省自然科学基金中央高校基本科研业务费专项资金太原市科学技术局科技兴市专项基金更多>>

温肾方调控外泌体ApoE4介导的胆固醇稳态改善甲减认知障碍的机制研究: 《时珍国医国药》2025年第3期440-447,共8页曾明星向楠陈继东邹小娟吴永贵卞庆来吴祖茜张海洋; 湖北省自然科学基金联合基金项目(2023AFD147);湖北省卫计委湖北中医名师工作室建设项目[鄂卫生计生办通(2018)15号];全国中医学术流派传承工作室第二轮建设项目(国中医药人教函[2019]62号)。; 目的基于外泌体ApoE4介导的胆固醇稳态研究温肾方对甲减认知障碍的作用。方法PTU溶解于饮用水中建立甲减模型,60只小鼠随机分为6组,每组10只,干预12周后,OFT、MWM进行行为学检测;生化法检测皮质和海马TC水平,Elisa法检测血清TT_(3)、TT_...; 关键词：甲状腺功能减退症认知障碍外泌体胆固醇稳态温肾方

Understanding genetics, sex and signaling: Implications of sex-dependent APOE4-neutrophil-microglia interactions for Alzheimer’s and tauopathies: 《Signal Transduction and Targeted Therapy》2024年第10期4167-4169,共3页Natja Haag Juliane Bremer Hans Zempel; A recent study published in Nature Medicine uncovers a novel sex-dependent mechanism involving the apolipoprotein E ε4 (APOE4) and in particular neutrophils and their signaling to microglia, which then would mediate ...; 关键词：ALZHEIMER tau Medicine

脑小血管病中APOE4携带与认知及步态的关系研究: 《中国老年保健医学》2024年第3期26-31,共6页何香花胡才友江东东黄金山梁梅张为; 广西医药卫生适宜技术开发与推广应用项目(编号:S2018012);广西自然科学基金项目(编号:2020GXNSFAA297189)。; 目的研究脑小血管病中APOE4携带与认知及步态的相关性。方法本研究共纳入119例脑小血管病患者,对这些患者进行APOE4基因分型、认知评估、单任务和双任务步态分析,并对上述结果进行统计学分析明确APOE4、认知和步态的关系。结果脑小血管...; 关键词：脑小血管病认知障碍步态单任务双任务

Apolipoprotein E4 interferes with lipid metabolism to exacerbate depression-like behaviors in 5xFAD mice: 《Animal Models and Experimental Medicine》2024年第3期347-361,共15页Yanju Gong Mingfeng Li Min Liu Xinghan Wu Yanhong Li Chuan Qin Ling Zhang; CAMS initiative for Innovative Medicine of China,Grant/Award Number:2021-I2M-1-034。; Background:Apolipoprotein E4(ApoE4)allele is the strongest genetic risk factor for late-onset Alzheimer's disease,and it can aggravate depressive symptoms in non-AD patients.However,the impact of ApoE4 on AD-associate...; 关键词：5xFAD mice Alzheimer's disease ApoE4 allele depression like

TRPV1 alleviates APOE4-dependent microglial antigen presentation and T cell infiltration in Alzheimer’s disease: 《Translational Neurodegeneration》2024年第1期300-323,共24页Jia Lu Kexin Wu Xudong Sha Jiayuan Lin Hongzhuan Chen Zhihua Yu; supported by grants from the National Natural Science Foundation of China(82173791);Science and Technology Commission of Shanghai Municipality(23ZR1436600).; Background Persistent innate and adaptive immune responses in the brain contribute to the progression of Alzhei-mer’s disease(AD).APOE4,the most important genetic risk factor for sporadic AD,encodes apolipoprotein E4...; 关键词：APOE4 CHOLESTEROL TRPV1 MICROGLIA Tau

Linking APOE4/4 genotype to microglial lipid droplets and neurotoxicity in Alzheimer’s disease: 《Translational Neurodegeneration》2024年第1期547-550,共4页Hao Huang Rong Xiang Riqiang Yan; supported by the National Natural Science Foundation of China(82300787,82170598);the Hunan Provincial Key Field R&D Plan Project(2022SK2034);the Natural Science Foundation of Hunan Province(2022JJ30058);the Youth Science Foundation of Xiangya Hospital(2021Q11).; Alzheimer’s disease(AD)is characterized by progressive cognitive decline and is a neurodegenerative disorder that primarily affects the elderly population worldwide.The main neuropathological features of AD include t...; 关键词：Alzheimer AMYLOID SPITE

Peripheral ApoE4 Leads to Cerebrovascular Dysfunction and Aβ Deposition in Alzheimer's Disease: 《Neuroscience Bulletin》2023年第8期1330-1332,共3页Rui Sun Chunming Xie; supported by the Science and Technology Innovation 2030 Major Projects(2022ZD0211600);the National Natural Science Foundation of China(82271574,82071204,81871069);the Key Projects of Commission of Health,Jiangsu Province(ZDB2020008).; Alzheimer's disease(AD)is a neurodegenerative disease characterized by progressive cognitive dysfunction and behavioral impairment that occurs in old age and pre-old age[1].Apolipoprotein4(ApoE4)is the most important ...; 关键词：APOE4 ALZHEIMER IMPAIRMENT

科学家找到了可缓解阿尔茨海默病的关键因子: 《人人健康》2023年第7期16-16,共1页本刊综合; 科学家们通过实验研究找到了可能导致阿尔茨海默病的关键因子——APOE4,并为这种致病机制提供了一个全新的分子机理解释。未来人们或可通过阻断神经元内APOE4的产生来达到减缓疾病发展的目的。; 关键词：阿尔茨海默病 APOE4 致病机制

APOE4通过少突胶质细胞的胆固醇失调损害髓鞘形成: 《中国临床药理学杂志》2023年第3期311-311,共1页; APOE4是阿尔茨海默病最强的遗传风险因子。然而,APOE4对人脑的影响尚未完全了解,这限制了针对携带APOE4和阿尔茨海默病其他危险因素的个体靶向治疗方法的开发机会。美国麻省理工学院Blanchard等研究发现,APOE4通过少突胶质细胞的胆固醇...; 关键词：髓鞘形成阿尔茨海默病少突胶质细胞基因表达变化携带者人类大脑靶向治疗细胞类型

LilrB3 is a putative cell surface receptor of APOE4被引量：6: 《Cell Research》2023年第2期116-130,共15页Jiayao Zhou Yumeng Wang Gaoxingyu Huang Min Yang Yumin Zhu Chen Jin Dan Jing Kai Ji Yigong Shi; National Key R&D Program of China(2020YFA0509300 to Y.S.);National Natural Science Foundation of China(81920108015 to Y.S.);Key R&D Program of Zhejiang Province(2020C04001 to Y.S.);Start-up funds from Westlake University.; The three isoforms of apolipoprotein E(APOE2,APOE3,and APOE4)only differ in two amino acid positions but exert quite different immunomodulatory effects.The underlying mechanism of such APOE isoform dependence remains ...; 关键词：SURFACE bringing APOE

APOE4