HSP90B1-mediated plasma membrane localization of GLUT1 promotes radioresistance of glioblastomas  

作　　者：Yanhui Li Yuqian Ge Mengjie Zhao Fangshu Ding Xiuxing Wang Zhumei Shi Xin Ge Xiefeng Wang Xu Qian 

机构地区：[1]Department of Nutrition and Food Hygiene,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China [2]Institute for Brain Tumors,Jiangsu Key Lab of Cancer Biomarkers,Prevention and Treatment,Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine,Nanjing Medical University,Nanjing,Jiangsu 211166,China [3]Department of Neuro-Psychiatric Institute,the Affiliated Brain Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China [4]National Health Commission Key Laboratory of Antibody Technologies,Nanjing Medical University,Nanjing,Jiangsu 211166,China [5]Department of Cell Biology,School of Basic Medical Sciences,Nanjing Medical University,Nanjing,Jiangsu 211166,China [6]Department of Neurosurgery,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China.

出　　处：《The Journal of Biomedical Research》2023年第5期326-339,共14页生物医学研究杂志（英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.82072765 to X.Q.and 82172667 to X.W.).

摘　　要：Ionizing radiation is a popular and effective treatment option for glioblastoma(GBM).However,resistance to radiation therapy inevitably occurs during treatment.It is urgent to investigate the mechanisms of radioresistance in GBM and to find ways to improve radiosensitivity.Here,we found that heat shock protein 90 beta family member 1(HSP90B1)was significantly upregulated in radioresistant GBM cell lines.More importantly,HSP90B1 promoted the localization of glucose transporter type 1,a key rate-limiting factor of glycolysis,on the plasma membrane,which in turn enhanced glycolytic activity and subsequently tumor growth and radioresistance of GBM cells.These findings imply that targeting HSP90B1 may effectively improve the efficacy of radiotherapy for GBM patients,a potential new approach to the treatment of glioblastoma.

关 键 词：HSP90B1 GLYCOLYSIS GLUT1 GLIOBLASTOMA radiotherapy 

分 类 号：R739.4[医药卫生—肿瘤]