Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies  

作　　者：Junjun Jing Zhuoxuan Wu Jiahe Wang Guowen Luo Hengyi Lin Yi Fan Chenchen Zhou 

机构地区：[1]State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China [2]Department of Pediatric Dentistry,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China [3]Department of Cariology and Endodontics,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第9期4082-4114,共33页信号转导与靶向治疗（英文）

基　　金：This work was supported by NSFC grants 82222015,82171001 and 81800928;Young Elite Scientist Sponsorship Program by CAST No.2020QNRC001;Research Funding from West China School/Hospital of Stomatology Sichuan University RCDWJS2023-(1).

摘　　要：The past decade has seen significant advances in our understanding of Hedgehog(HH)signaling pathway in various biological events.HH signaling pathway exerts its biological effects through a complex signaling cascade involved with primary cilium.HH signaling pathway has important functions in embryonic development and tissue homeostasis.It plays a central role in the regulation of the proliferation and differentiation of adult stem cells.Importantly,it has become increasingly clear that HH signaling pathway is associated with increased cancer prevalence,malignant progression,poor prognosis and even increased mortality.Understanding the integrative nature of HH signaling pathway has opened up the potential for new therapeutic targets for cancer.A variety of drugs have been developed,including small molecule inhibitors,natural compounds,and long non-coding RNA(LncRNA),some of which are approved for clinical use.This review outlines recent discoveries of HH signaling in tissue homeostasis and cancer and discusses how these advances are paving the way for the development of new biologically based therapies for cancer.Furthermore,we address status quo and limitations of targeted therapies of HH signaling pathway.Insights from this review will help readers understand the function of HH signaling in homeostasis and cancer,as well as opportunities and challenges of therapeutic targets for cancer.

关 键 词：HOMEOSTASIS THERAPIES TARGETED 

分 类 号：R730.5[医药卫生—肿瘤]