Lactate:a prospective target for therapeutic intervention in psychiatric disease  

作　　者：Yanhui Cai Haiyun Guo Tianle Han Huaning Wang 

机构地区：[1]Department of Psychiatry,Xijing Hospital,Fourth Military Medical University,Xi’an,Shaanxi Province,China [2]Department of Anesthesiology and Perioperative Medicine,Xijing Hospital,Fourth Military Medical University,Xi’an,Shaanxi Province,China

出　　处：《Neural Regeneration Research》2024年第7期1473-1479,共7页中国神经再生研究（英文版）

基　　金：financially supported by the National Nature Science Foundation of China,Nos.82271508(to YC)82001384(to YC)82271316(to HG)。

摘　　要：Although antipsychotics that act via monoaminergic neurotransmitter modulation have considera ble therapeutic effect,they cannot completely relieve clinical symptoms in patients suffering from psychiatric disorde rs.This may be attributed to the limited range of neurotransmitters that are regulated by psychotropic drugs.Recent findings indicate the need for investigation of psychotropic medications that target less-studied neurotransmitte rs.Among these candidate neurotransmitters,lactate is developing from being a waste metabolite to a glial-neuronal signaling molecule in recent years.Previous studies have suggested that cerebral lactate levels change considerably in numerous psychiatric illnesses;animal experiments have also shown that the supply of exogenous la ctate exerts an antidepressant effect.In this review,we have described how medications targeting newer neurotransmitte rs offer promise in psychiatric diseases;we have also summarized the advances in the use of lactate(and its corresponding signaling pathways)as a signaling molecule.In addition,we have described the alterations in brain lactate levels in depression,anxiety,bipolar disorder,and schizophrenia and have indicated the challenges that need to be overcome before brain lactate can be used as a therapeutic target in psychopharmacology.

关 键 词：ANTIDEPRESSANT ANXIETY bipolar disorder depression LACTATE psychiatric disease PSYCHOPHARMACOLOGY SCHIZOPHRENIA signal molecular THERAPEUTICS 

分 类 号：R749[医药卫生—神经病学与精神病学]