Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets  

作　　者：Chao Gao Jingwen Jiang Yuyan Tan Shengdi Chen 

机构地区：[1]Department of Neurology,Rujin Hospital,Shanghai Jiao Tong University School of Medicine,200025 Shanghai,China [2]Lab for Translational Research of Neurodegenerative Diseases,Shanghai Institute for Advanced Immunochemical Studies(SIAIS),Shanghai Tech University,201210 Shanghai,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第10期4746-4782,共37页信号转导与靶向治疗（英文）

基　　金：This research was funded by the National Natural Science Foundation of China(81971187,82171401,81971183,and 82101477);Shanghai Municipal Science and Technology Major Project(2018SHZDZX05);Innovation Program of Shanghai Municipal Education Commission(2017-01-07-00-01-E00046).

摘　　要：Microglia activation is observed in various neurodegenerative diseases.Recent advances in single-cell technologies have revealed that these reactive microglia were with high spatial and temporal heterogeneity.Some identified microglia in specific states correlate with pathological hallmarks and are associated with specific functions.

关 键 词：DEGENERATIVE HETEROGENEITY FUNCTIONS 

分 类 号：R741[医药卫生—神经病学与精神病学]